Numerical Optimization Studies of Cardiovascular-Rotary Blood Pump Interaction

Einly Lim, Socrates Dokos, Robert F. Salamonsen, Franklin L. Rosenfeldt, Peter J. Ayre, Nigel H. Lovell

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)


A heart-pump interaction model has been developed based on animal experimental measurements obtained with a rotary blood pump in situ. Five canine experiments were performed to investigate the interaction between the cardiovascular system and the implantable rotary blood pump over a wide range of operating conditions, including variations in cardiac contractility and heart rate, systemic vascular resistance (SVR), and total blood volume (V total). It was observed in our experiments that SVR decreased with increasing mean pump speed under the healthy condition, but was relatively constant during the speed ramp study under reduced cardiac contractility conditions. Furthermore, we also found a significant increase in pulmonary vascular resistance with increasing mean pump speed and decreasing total blood volume, despite a relatively constant SVR. Least squares parameter estimation methods were utilized to fit a subset of model parameters in order to achieve better agreement with the experimental data and to evaluate the robustness and validity of the model under various operating conditions. The fitted model produced reasonable agreement with the experimental measurements, both in terms of mean values and steady-state waveforms. In addition, all the optimized parameters were within physiological limits.

Original languageEnglish
Pages (from-to)E110-E124
Number of pages15
JournalArtificial Organs
Issue number5
Publication statusPublished - May 2012
Externally publishedYes


  • Heart failure
  • Heart-pump interaction model
  • Implantable rotary blood pump
  • Ventricular assist devices

Cite this