Nucleolar and cytoplasmic localization of annexin V

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The subcellular localization of annexin V in cultured human umbilical vein endothelial cells, epithelial cells and fibroblasts was examined. Indirect immunofluorescence and immunoblotting studies using affinity-purified anti-annexin V antibodies revealed that annexin V is located within the cytoplasm and nucleus of these cells. Further examination and direct binding studies showed that annexin V within the nucleus is associated with the nucleolus. These findings suggest that annexin V may play a role in a nucleolar function, such as ribosome assembly and transport.

Original languageEnglish
Pages (from-to)425-429
Number of pages5
JournalFEBS Letters
Issue number3
Publication statusPublished - 21 Dec 1992
Externally publishedYes


  • Annexin V
  • Endothelial cell
  • Nucleolus

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