Nuclear Transfer for Stem Cells

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Abstract

Somatic cell nuclear transfer for pluripotent stem cells is established for animal species, in particular in the mouse and non-human primates. However, there have been major difficulties in deriving pluripotent stem cells by nuclear transfer in the human. Despite this difficulty, there are strong interests in establishing somatic cell nuclear transfer (SCNT) in the human for study of early human development, production of gametes for infertile/sterile patients, comparisons of developmental and differentiation potential with induced pluripotential stem cells (iPSCs), and research in stem cell biology. The combination of oocyte derived factors and transcription factors for efficient and effective reprogramming of somatic nuclei for pluripotent stem cells is a strong inducement for further research in SCNT.

Original languageEnglish
Title of host publicationPrinciples of Cloning: Second Edition
PublisherElsevier
Pages313-316
Number of pages4
ISBN (Print)9780123865410
DOIs
Publication statusPublished - Oct 2013
Externally publishedYes

Keywords

  • Development
  • Differentiation
  • Embryonic stem cells
  • Induced pluripotent stem cells
  • Nuclear reprogramming
  • Oocyte reprogramming factors
  • Pluripotent stem cells
  • Somatic cell nuclear transfer

Cite this

Trounson, A. (2013). Nuclear Transfer for Stem Cells. In Principles of Cloning: Second Edition (pp. 313-316). Elsevier. https://doi.org/10.1016/B978-0-12-386541-0.00024-2