Nuclear receptor expression in human differentiated thyroid tumors

Michael Mond, Maria Alexiadis, Natalie Eriksson, Melissa J Davis, George E O Muscat, Peter J Fuller, Christopher P Gilfillan

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Background: Nuclear receptors (NRs) play a key role in endocrine signaling and metabolism and are important therapeutic targets in a number of hormone-dependent malignancies. Studies on the role of NRs in thyroid cancer are limited. Objective: The objective of the study was to examine systematically the expression of the 48 human NRs in a series of benign and malignant thyroid tissues. Within the papillary carcinoma cohort, we sought to determine if NR expression differed significantly by BRAF mutation status.
Original languageEnglish
Pages (from-to)1000 - 1011
Number of pages12
JournalThyroid
Volume24
Issue number6
DOIs
Publication statusPublished - 2014

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