Nuclear receptor expression in human differentiated thyroid tumors

Michael Mond; Maria Alexiadis; Natalie Eriksson; Melissa J Davis; George E O Muscat; Peter J Fuller; Christopher P Gilfillan

doi:10.1089/thy.2013.0509

Nuclear receptor expression in human differentiated thyroid tumors

Michael Mond, Maria Alexiadis, Natalie Eriksson, Melissa J Davis, George E O Muscat, Peter J Fuller, Christopher P Gilfillan

Eastern Health Clinical School

Research output: Contribution to journal › Article › Research › peer-review

13 Citations (Scopus)

Abstract

Background: Nuclear receptors (NRs) play a key role in endocrine signaling and metabolism and are important therapeutic targets in a number of hormone-dependent malignancies. Studies on the role of NRs in thyroid cancer are limited. Objective: The objective of the study was to examine systematically the expression of the 48 human NRs in a series of benign and malignant thyroid tissues. Within the papillary carcinoma cohort, we sought to determine if NR expression differed significantly by BRAF mutation status.

Original language	English
Pages (from-to)	1000 - 1011
Number of pages	12
Journal	Thyroid
Volume	24
Issue number	6
DOIs	https://doi.org/10.1089/thy.2013.0509
Publication status	Published - 2014

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10.1089/thy.2013.0509

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Cite this

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AU - Mond, Michael

AU - Alexiadis, Maria

AU - Eriksson, Natalie

AU - Davis, Melissa J

AU - Muscat, George E O

AU - Fuller, Peter J

AU - Gilfillan, Christopher P

PY - 2014

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N2 - Background: Nuclear receptors (NRs) play a key role in endocrine signaling and metabolism and are important therapeutic targets in a number of hormone-dependent malignancies. Studies on the role of NRs in thyroid cancer are limited. Objective: The objective of the study was to examine systematically the expression of the 48 human NRs in a series of benign and malignant thyroid tissues. Within the papillary carcinoma cohort, we sought to determine if NR expression differed significantly by BRAF mutation status.

AB - Background: Nuclear receptors (NRs) play a key role in endocrine signaling and metabolism and are important therapeutic targets in a number of hormone-dependent malignancies. Studies on the role of NRs in thyroid cancer are limited. Objective: The objective of the study was to examine systematically the expression of the 48 human NRs in a series of benign and malignant thyroid tissues. Within the papillary carcinoma cohort, we sought to determine if NR expression differed significantly by BRAF mutation status.

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DO - 10.1089/thy.2013.0509

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