N6-(5,6-epoxynorbornyl)adenosine analogs as A1adenosine agonists

Denis M.J. Wright; Stephen P. Baker; Scott G. Stewart; Peter J. Scammells

doi:10.1016/S0960-894X(98)00668-4

N⁶-(5,6-epoxynorbornyl)adenosine analogs as A1adenosine agonists

Denis M.J. Wright, Stephen P. Baker, Scott G. Stewart, Peter J. Scammells

Medicinal Chemistry

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

A range of related adenosines and 5'-N-ethylcarboxamidoadenosines bearing oxygenated substituents in the N6position have been synthesised and evaluated as A1-adenosine receptor ligands. Compound 9 emerged with potent affinity (EC50= 1.1 nM).

Original language	English
Pages (from-to)	3647-3648
Number of pages	2
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	24
DOIs	https://doi.org/10.1016/S0960-894X(98)00668-4
Publication status	Published - 15 Dec 1998

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10.1016/S0960-894X(98)00668-4

Cite this

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title = "N6-(5,6-epoxynorbornyl)adenosine analogs as A1adenosine agonists",

abstract = "A range of related adenosines and 5'-N-ethylcarboxamidoadenosines bearing oxygenated substituents in the N6position have been synthesised and evaluated as A1-adenosine receptor ligands. Compound 9 emerged with potent affinity (EC50= 1.1 nM).",

author = "Wright, {Denis M.J.} and Baker, {Stephen P.} and Stewart, {Scott G.} and Scammells, {Peter J.}",

year = "1998",

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T1 - N6-(5,6-epoxynorbornyl)adenosine analogs as A1adenosine agonists

AU - Wright, Denis M.J.

AU - Baker, Stephen P.

AU - Stewart, Scott G.

AU - Scammells, Peter J.

PY - 1998/12/15

Y1 - 1998/12/15

N2 - A range of related adenosines and 5'-N-ethylcarboxamidoadenosines bearing oxygenated substituents in the N6position have been synthesised and evaluated as A1-adenosine receptor ligands. Compound 9 emerged with potent affinity (EC50= 1.1 nM).

AB - A range of related adenosines and 5'-N-ethylcarboxamidoadenosines bearing oxygenated substituents in the N6position have been synthesised and evaluated as A1-adenosine receptor ligands. Compound 9 emerged with potent affinity (EC50= 1.1 nM).

UR - http://www.scopus.com/inward/record.url?scp=0032534219&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(98)00668-4

DO - 10.1016/S0960-894X(98)00668-4

M3 - Article

C2 - 9934487

AN - SCOPUS:0032534219

VL - 8

SP - 3647

EP - 3648

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 24

ER -

N6-(5,6-epoxynorbornyl)adenosine analogs as A1adenosine agonists

Abstract

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N⁶-(5,6-epoxynorbornyl)adenosine analogs as A1adenosine agonists