Novel Strategies to Protect and Visualize Pancreatic β Cells in Diabetes

Esteban N. Gurzov, Pu Chun Ke, Ulf Ahlgren, Rita S. Garcia Ribeiro, Martin Gotthardt

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

A common feature in the pathophysiology of different types of diabetes is the reduction of β cell mass and/or impairment of β cell function. Diagnosis and treatment of type 1 and type 2 diabetes is currently hampered by a lack of reliable techniques to restore β cell survival, to improve insulin secretion, and to quantify β cell mass in patients. Current new approaches may allow us to precisely and specifically visualize β cells in vivo and provide viable therapeutic strategies to preserve, recover, and regenerate β cells. In this review, we discuss recent protective approaches for β cells and the advantages and limitations of current imaging probes in the field.

Original languageEnglish
Pages (from-to)905-917
Number of pages13
JournalTrends in Endocrinology & Metabolism
Volume31
Issue number12
DOIs
Publication statusPublished - 1 Dec 2020

Keywords

  • nanomaterials
  • type 1 diabetes
  • type 2 diabetes
  • β cell dysfunction
  • β cell imaging

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