Novel Strategies to Protect and Visualize Pancreatic β Cells in Diabetes

Esteban N. Gurzov; Pu Chun Ke; Ulf Ahlgren; Rita S. Garcia Ribeiro; Martin Gotthardt

doi:10.1016/j.tem.2020.10.002

Novel Strategies to Protect and Visualize Pancreatic β Cells in Diabetes

Esteban N. Gurzov, Pu Chun Ke, Ulf Ahlgren, Rita S. Garcia Ribeiro, Martin Gotthardt

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Review Article › Research › peer-review

15 Citations (Scopus)

Abstract

A common feature in the pathophysiology of different types of diabetes is the reduction of β cell mass and/or impairment of β cell function. Diagnosis and treatment of type 1 and type 2 diabetes is currently hampered by a lack of reliable techniques to restore β cell survival, to improve insulin secretion, and to quantify β cell mass in patients. Current new approaches may allow us to precisely and specifically visualize β cells in vivo and provide viable therapeutic strategies to preserve, recover, and regenerate β cells. In this review, we discuss recent protective approaches for β cells and the advantages and limitations of current imaging probes in the field.

Original language	English
Pages (from-to)	905-917
Number of pages	13
Journal	Trends in Endocrinology and Metabolism
Volume	31
Issue number	12
DOIs	https://doi.org/10.1016/j.tem.2020.10.002
Publication status	Published - 1 Dec 2020

Keywords

nanomaterials
type 1 diabetes
type 2 diabetes
β cell dysfunction
β cell imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tem.2020.10.002

Cite this

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abstract = "A common feature in the pathophysiology of different types of diabetes is the reduction of β cell mass and/or impairment of β cell function. Diagnosis and treatment of type 1 and type 2 diabetes is currently hampered by a lack of reliable techniques to restore β cell survival, to improve insulin secretion, and to quantify β cell mass in patients. Current new approaches may allow us to precisely and specifically visualize β cells in vivo and provide viable therapeutic strategies to preserve, recover, and regenerate β cells. In this review, we discuss recent protective approaches for β cells and the advantages and limitations of current imaging probes in the field.",

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AU - Gurzov, Esteban N.

AU - Ke, Pu Chun

AU - Ahlgren, Ulf

AU - Garcia Ribeiro, Rita S.

AU - Gotthardt, Martin

PY - 2020/12/1

Y1 - 2020/12/1

N2 - A common feature in the pathophysiology of different types of diabetes is the reduction of β cell mass and/or impairment of β cell function. Diagnosis and treatment of type 1 and type 2 diabetes is currently hampered by a lack of reliable techniques to restore β cell survival, to improve insulin secretion, and to quantify β cell mass in patients. Current new approaches may allow us to precisely and specifically visualize β cells in vivo and provide viable therapeutic strategies to preserve, recover, and regenerate β cells. In this review, we discuss recent protective approaches for β cells and the advantages and limitations of current imaging probes in the field.

AB - A common feature in the pathophysiology of different types of diabetes is the reduction of β cell mass and/or impairment of β cell function. Diagnosis and treatment of type 1 and type 2 diabetes is currently hampered by a lack of reliable techniques to restore β cell survival, to improve insulin secretion, and to quantify β cell mass in patients. Current new approaches may allow us to precisely and specifically visualize β cells in vivo and provide viable therapeutic strategies to preserve, recover, and regenerate β cells. In this review, we discuss recent protective approaches for β cells and the advantages and limitations of current imaging probes in the field.

KW - nanomaterials

KW - type 1 diabetes

KW - type 2 diabetes

KW - β cell dysfunction

KW - β cell imaging

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Novel Strategies to Protect and Visualize Pancreatic β Cells in Diabetes

Abstract

Keywords

UN SDGs

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Other files and links

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

Cite this

Novel Strategies to Protect and Visualize Pancreatic β Cells in Diabetes

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

Cite this