Novel risk factors for acute coronary syndromes and emerging therapies

David C. Tong, Andrew M. Wilson, Jamie Layland

Research output: Contribution to journalReview ArticleResearchpeer-review

10 Citations (Scopus)


Acute coronary syndromes represent not merely disrupted atherosclerotic plaques or luminal stenoses but rather a complex clinical syndrome. The traditional conception of pathogenesis and management of ACS has been challenged by numerous recent landmark ACS trials. Current prognostication models lack clinical precision and can be challenging to the clinicians in tailoring management strategies for individual patients. In this review we summarise the emerging evidence of novel risk factors (plaque phenotype, coronary blood flow, endothelial dysfunction, microvascular dysfunction, and inflammation) in predicting future events and outcomes in ACS population. As the search for miracle cure for ischaemic heart disease continues, one is hopeful that emerging therapeutic approaches targeting these novel risk factors will improve long-term outcomes of ACS.

Original languageEnglish
Pages (from-to)815-824
Number of pages10
JournalInternational Journal of Cardiology
Publication statusPublished - 1 Oct 2016


  • Acute coronary syndromes
  • Atherosclerosis
  • Ischaemic heart disease
  • Risk

Cite this