TY - JOUR
T1 - Novel polymeric dressing to the treatment of infected chronic wound
AU - Garms, Bruna Cambraia
AU - Borges, Felipe Azevedo
AU - de Barros, Natan Roberto
AU - Marcelino, Mônica Yonashiro
AU - Leite, Marcel Nani
AU - Del Arco, Marina Constante
AU - de Souza Salvador, Sérgio Luiz
AU - Pegorin, Giovana Sant’Ana
AU - Oliveira, Kassandra Sussi Mustafé
AU - Frade, Marco Andrey Cipriani
AU - Herculano, Rondinelli Donizetti
N1 - Funding Information:
Funding The authors gratefully acknowledge the support of CNPq, National Council for Scientific and Technological Development (no. 470261/2012-9 and no. 134018/2016-8), and FAPESP, São Paulo Research Foundation (no. 2014/17526-8 and no. 2011/17411-8).
Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2019/6/18
Y1 - 2019/6/18
N2 - Natural rubber latex (NRL) is a natural polymer which has arisen large interest in the biomedical field, mostly, due to its ability to facilitate angiogenesis and therefore, tissue repair. Moxifloxacin (MXF) is a broad-spectrum antibiotic orally administrated. Considering the biological properties of the NRL and its ability to deliver a wide range of compounds, the present study aimed to develop a novel device for infected chronic wound treatment. MXF-loaded NRL was obtained by a casting method. The results demonstrated that the incorporation of MXF in NRL did not promote any molecular interaction, preserving the integrity of the compounds. The mechanical properties of the biomaterial did not show any significant change, indicating enough elasticity for dermal application. The microbiological assays confirmed the ability of the polymer to deliver the drug without influencing its pharmacological properties. Moreover, it has expressed activity against major bacterial strains presented in wound infections. Finally, the biomaterial shown biocompatibility from the in vitro study. Thus, the present work has shown that MXF-loaded NRL membrane is a promising biomaterial to infected wound treatment.
AB - Natural rubber latex (NRL) is a natural polymer which has arisen large interest in the biomedical field, mostly, due to its ability to facilitate angiogenesis and therefore, tissue repair. Moxifloxacin (MXF) is a broad-spectrum antibiotic orally administrated. Considering the biological properties of the NRL and its ability to deliver a wide range of compounds, the present study aimed to develop a novel device for infected chronic wound treatment. MXF-loaded NRL was obtained by a casting method. The results demonstrated that the incorporation of MXF in NRL did not promote any molecular interaction, preserving the integrity of the compounds. The mechanical properties of the biomaterial did not show any significant change, indicating enough elasticity for dermal application. The microbiological assays confirmed the ability of the polymer to deliver the drug without influencing its pharmacological properties. Moreover, it has expressed activity against major bacterial strains presented in wound infections. Finally, the biomaterial shown biocompatibility from the in vitro study. Thus, the present work has shown that MXF-loaded NRL membrane is a promising biomaterial to infected wound treatment.
KW - Antibiotic
KW - Moxifloxacin
KW - Natural rubber latex
KW - Skin infection
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=85065483629&partnerID=8YFLogxK
U2 - 10.1007/s00253-019-09699-x
DO - 10.1007/s00253-019-09699-x
M3 - Article
C2 - 31065753
AN - SCOPUS:85065483629
SN - 0175-7598
VL - 103
SP - 4767
EP - 4778
JO - Applied Microbiology and Biotechnology
JF - Applied Microbiology and Biotechnology
IS - 12
ER -