Novel polymeric dressing to the treatment of infected chronic wound

Bruna Cambraia Garms, Felipe Azevedo Borges, Natan Roberto de Barros, Mônica Yonashiro Marcelino, Marcel Nani Leite, Marina Constante Del Arco, Sérgio Luiz de Souza Salvador, Giovana Sant’Ana Pegorin, Kassandra Sussi Mustafé Oliveira, Marco Andrey Cipriani Frade, Rondinelli Donizetti Herculano

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26 Citations (Scopus)

Abstract

Natural rubber latex (NRL) is a natural polymer which has arisen large interest in the biomedical field, mostly, due to its ability to facilitate angiogenesis and therefore, tissue repair. Moxifloxacin (MXF) is a broad-spectrum antibiotic orally administrated. Considering the biological properties of the NRL and its ability to deliver a wide range of compounds, the present study aimed to develop a novel device for infected chronic wound treatment. MXF-loaded NRL was obtained by a casting method. The results demonstrated that the incorporation of MXF in NRL did not promote any molecular interaction, preserving the integrity of the compounds. The mechanical properties of the biomaterial did not show any significant change, indicating enough elasticity for dermal application. The microbiological assays confirmed the ability of the polymer to deliver the drug without influencing its pharmacological properties. Moreover, it has expressed activity against major bacterial strains presented in wound infections. Finally, the biomaterial shown biocompatibility from the in vitro study. Thus, the present work has shown that MXF-loaded NRL membrane is a promising biomaterial to infected wound treatment.

Original languageEnglish
Pages (from-to)4767-4778
Number of pages12
JournalApplied Microbiology and Biotechnology
Volume103
Issue number12
DOIs
Publication statusPublished - 18 Jun 2019
Externally publishedYes

Keywords

  • Antibiotic
  • Moxifloxacin
  • Natural rubber latex
  • Skin infection
  • Wound healing

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