Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients

Brendan J McMorran; Severine A Ouvry Patat; John B Carlin; Keith Grimwood; Alun Jones; David Stuart Armstrong; John C Galati; Peter J Cooper; Catherine A Byrnes; Paul W Francis; Colin F Robertson; David A Hume; Christoph H Borchers; Claire E Wainwright; Brandon Wainwright

Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients

Brendan J McMorran, Severine A Ouvry Patat, John B Carlin, Keith Grimwood, Alun Jones, David Stuart Armstrong, John C Galati, Peter J Cooper, Catherine A Byrnes, Paul W Francis, Colin F Robertson, David A Hume, Christoph H Borchers, Claire E Wainwright, Brandon Wainwright

Paediatrics Monash Health

Research output: Contribution to journal › Article › Research › peer-review

41 Citations (Scopus)

Abstract

BACKGROUND: Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophil-mediated tissue destruction, but its genesis and mechanisms remain poorly understood. To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection. METHODS: We collected BALF samples from 45 children younger than 5 years and grouped them according to the presence of respiratory pathogens: > or = 1 x 10(5) colony-forming units (CFU)/mL BALF (18 and 12 samples with and without CF, respectively) and

Original language	English
Pages (from-to)	1782 - 1791
Number of pages	10
Journal	Clinical Chemistry
Volume	53
Issue number	10
Publication status	Published - 2007

Cite this

McMorran, B. J., Ouvry Patat, S. A., Carlin, J. B., Grimwood, K., Jones, A., Armstrong, D. S., Galati, J. C., Cooper, P. J., Byrnes, C. A., Francis, P. W., Robertson, C. F., Hume, D. A., Borchers, C. H., Wainwright, C. E., & Wainwright, B. (2007). Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients. Clinical Chemistry, 53(10), 1782 - 1791.

@article{28a233c6ff8a47dbbcb62cec7de84063,

title = "Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients",

abstract = "BACKGROUND: Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophil-mediated tissue destruction, but its genesis and mechanisms remain poorly understood. To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection. METHODS: We collected BALF samples from 45 children younger than 5 years and grouped them according to the presence of respiratory pathogens: > or = 1 x 10(5) colony-forming units (CFU)/mL BALF (18 and 12 samples with and without CF, respectively) and",

author = "McMorran, \{Brendan J\} and \{Ouvry Patat\}, \{Severine A\} and Carlin, \{John B\} and Keith Grimwood and Alun Jones and Armstrong, \{David Stuart\} and Galati, \{John C\} and Cooper, \{Peter J\} and Byrnes, \{Catherine A\} and Francis, \{Paul W\} and Robertson, \{Colin F\} and Hume, \{David A\} and Borchers, \{Christoph H\} and Wainwright, \{Claire E\} and Brandon Wainwright",

year = "2007",

language = "English",

volume = "53",

pages = "1782 -- 1791",

journal = "Clinical Chemistry",

issn = "0009-9147",

publisher = "Oxford University Press, USA",

number = "10",

}

McMorran, BJ, Ouvry Patat, SA, Carlin, JB, Grimwood, K, Jones, A, Armstrong, DS, Galati, JC, Cooper, PJ, Byrnes, CA, Francis, PW, Robertson, CF, Hume, DA, Borchers, CH, Wainwright, CE & Wainwright, B 2007, 'Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients', Clinical Chemistry, vol. 53, no. 10, pp. 1782 - 1791.

TY - JOUR

T1 - Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients

AU - McMorran, Brendan J

AU - Ouvry Patat, Severine A

AU - Carlin, John B

AU - Grimwood, Keith

AU - Jones, Alun

AU - Armstrong, David Stuart

AU - Galati, John C

AU - Cooper, Peter J

AU - Byrnes, Catherine A

AU - Francis, Paul W

AU - Robertson, Colin F

AU - Hume, David A

AU - Borchers, Christoph H

AU - Wainwright, Claire E

AU - Wainwright, Brandon

PY - 2007

Y1 - 2007

N2 - BACKGROUND: Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophil-mediated tissue destruction, but its genesis and mechanisms remain poorly understood. To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection. METHODS: We collected BALF samples from 45 children younger than 5 years and grouped them according to the presence of respiratory pathogens: > or = 1 x 10(5) colony-forming units (CFU)/mL BALF (18 and 12 samples with and without CF, respectively) and

AB - BACKGROUND: Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophil-mediated tissue destruction, but its genesis and mechanisms remain poorly understood. To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection. METHODS: We collected BALF samples from 45 children younger than 5 years and grouped them according to the presence of respiratory pathogens: > or = 1 x 10(5) colony-forming units (CFU)/mL BALF (18 and 12 samples with and without CF, respectively) and

UR - http://www.clinchem.org/cgi/reprint/53/10/1782

UR - https://www.scopus.com/pages/publications/34848901700

M3 - Article

SN - 0009-9147

VL - 53

SP - 1782

EP - 1791

JO - Clinical Chemistry

JF - Clinical Chemistry

IS - 10

ER -

Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients

Abstract

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