Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients

Brendan J McMorran, Severine A Ouvry Patat, John B Carlin, Keith Grimwood, Alun Jones, David Stuart Armstrong, John C Galati, Peter J Cooper, Catherine A Byrnes, Paul W Francis, Colin F Robertson, David A Hume, Christoph H Borchers, Claire E Wainwright, Brandon Wainwright

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Abstract

BACKGROUND: Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophil-mediated tissue destruction, but its genesis and mechanisms remain poorly understood. To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection. METHODS: We collected BALF samples from 45 children younger than 5 years and grouped them according to the presence of respiratory pathogens: > or = 1 x 10(5) colony-forming units (CFU)/mL BALF (18 and 12 samples with and without CF, respectively) and
Original languageEnglish
Pages (from-to)1782 - 1791
Number of pages10
JournalClinical Chemistry
Volume53
Issue number10
Publication statusPublished - 2007

Cite this

McMorran, B. J., Ouvry Patat, S. A., Carlin, J. B., Grimwood, K., Jones, A., Armstrong, D. S., Galati, J. C., Cooper, P. J., Byrnes, C. A., Francis, P. W., Robertson, C. F., Hume, D. A., Borchers, C. H., Wainwright, C. E., & Wainwright, B. (2007). Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients. Clinical Chemistry, 53(10), 1782 - 1791.