Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients

Brendan J McMorran, Severine A Ouvry Patat, John B Carlin, Keith Grimwood, Alun Jones, David Stuart Armstrong, John C Galati, Peter J Cooper, Catherine A Byrnes, Paul W Francis, Colin F Robertson, David A Hume, Christoph H Borchers, Claire E Wainwright, Brandon Wainwright

Research output: Contribution to journalArticleResearchpeer-review

Abstract

BACKGROUND: Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophil-mediated tissue destruction, but its genesis and mechanisms remain poorly understood. To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection. METHODS: We collected BALF samples from 45 children younger than 5 years and grouped them according to the presence of respiratory pathogens: > or = 1 x 10(5) colony-forming units (CFU)/mL BALF (18 and 12 samples with and without CF, respectively) and
Original languageEnglish
Pages (from-to)1782 - 1791
Number of pages10
JournalClinical Chemistry
Volume53
Issue number10
Publication statusPublished - 2007

Cite this

McMorran, B. J., Ouvry Patat, S. A., Carlin, J. B., Grimwood, K., Jones, A., Armstrong, D. S., ... Wainwright, B. (2007). Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients. Clinical Chemistry, 53(10), 1782 - 1791.
McMorran, Brendan J ; Ouvry Patat, Severine A ; Carlin, John B ; Grimwood, Keith ; Jones, Alun ; Armstrong, David Stuart ; Galati, John C ; Cooper, Peter J ; Byrnes, Catherine A ; Francis, Paul W ; Robertson, Colin F ; Hume, David A ; Borchers, Christoph H ; Wainwright, Claire E ; Wainwright, Brandon. / Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients. In: Clinical Chemistry. 2007 ; Vol. 53, No. 10. pp. 1782 - 1791.
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title = "Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients",
abstract = "BACKGROUND: Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophil-mediated tissue destruction, but its genesis and mechanisms remain poorly understood. To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection. METHODS: We collected BALF samples from 45 children younger than 5 years and grouped them according to the presence of respiratory pathogens: > or = 1 x 10(5) colony-forming units (CFU)/mL BALF (18 and 12 samples with and without CF, respectively) and",
author = "McMorran, {Brendan J} and {Ouvry Patat}, {Severine A} and Carlin, {John B} and Keith Grimwood and Alun Jones and Armstrong, {David Stuart} and Galati, {John C} and Cooper, {Peter J} and Byrnes, {Catherine A} and Francis, {Paul W} and Robertson, {Colin F} and Hume, {David A} and Borchers, {Christoph H} and Wainwright, {Claire E} and Brandon Wainwright",
year = "2007",
language = "English",
volume = "53",
pages = "1782 -- 1791",
journal = "Clinical Chemistry",
issn = "0009-9147",
publisher = "American Association for Clinical Chemistry",
number = "10",

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McMorran, BJ, Ouvry Patat, SA, Carlin, JB, Grimwood, K, Jones, A, Armstrong, DS, Galati, JC, Cooper, PJ, Byrnes, CA, Francis, PW, Robertson, CF, Hume, DA, Borchers, CH, Wainwright, CE & Wainwright, B 2007, 'Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients' Clinical Chemistry, vol. 53, no. 10, pp. 1782 - 1791.

Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients. / McMorran, Brendan J; Ouvry Patat, Severine A; Carlin, John B; Grimwood, Keith; Jones, Alun; Armstrong, David Stuart; Galati, John C; Cooper, Peter J; Byrnes, Catherine A; Francis, Paul W; Robertson, Colin F; Hume, David A; Borchers, Christoph H; Wainwright, Claire E; Wainwright, Brandon.

In: Clinical Chemistry, Vol. 53, No. 10, 2007, p. 1782 - 1791.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients

AU - McMorran, Brendan J

AU - Ouvry Patat, Severine A

AU - Carlin, John B

AU - Grimwood, Keith

AU - Jones, Alun

AU - Armstrong, David Stuart

AU - Galati, John C

AU - Cooper, Peter J

AU - Byrnes, Catherine A

AU - Francis, Paul W

AU - Robertson, Colin F

AU - Hume, David A

AU - Borchers, Christoph H

AU - Wainwright, Claire E

AU - Wainwright, Brandon

PY - 2007

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N2 - BACKGROUND: Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophil-mediated tissue destruction, but its genesis and mechanisms remain poorly understood. To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection. METHODS: We collected BALF samples from 45 children younger than 5 years and grouped them according to the presence of respiratory pathogens: > or = 1 x 10(5) colony-forming units (CFU)/mL BALF (18 and 12 samples with and without CF, respectively) and

AB - BACKGROUND: Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophil-mediated tissue destruction, but its genesis and mechanisms remain poorly understood. To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection. METHODS: We collected BALF samples from 45 children younger than 5 years and grouped them according to the presence of respiratory pathogens: > or = 1 x 10(5) colony-forming units (CFU)/mL BALF (18 and 12 samples with and without CF, respectively) and

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