Abstract
Size is important: Noncovalent nanoparticles are formed by the self-assembly of glycodendrimers containing both a ligand and a self-assembling moiety. Particle size reaches an optimum at the second and third generation, larger dendritic species show less efficient self-assembly. It is the nanoparticles, not the individual molecules, that governs their potency as polyvalent receptor blockers (see scheme), both in vitro and in vivo.
Original language | English |
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Pages (from-to) | 3195-3198 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 41 |
Issue number | 17 |
DOIs | |
Publication status | Published - 2 Sep 2002 |
Externally published | Yes |
Keywords
- Aggregation
- Carbohydrates
- Dendrimers
- Polyvalence
- Supramolecular chemistry