Novel glycodendrimers self-assemble to nanoparticles which function as polyvalent ligands in vitro and in vivo

Gebhard Thoma, Andreas G. Katopodis, Nicolas Voelcker, Rudolf O. Duthaler, Markus B. Streiff

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Abstract

Size is important: Noncovalent nanoparticles are formed by the self-assembly of glycodendrimers containing both a ligand and a self-assembling moiety. Particle size reaches an optimum at the second and third generation, larger dendritic species show less efficient self-assembly. It is the nanoparticles, not the individual molecules, that governs their potency as polyvalent receptor blockers (see scheme), both in vitro and in vivo.

Original languageEnglish
Pages (from-to)3195-3198
Number of pages4
JournalAngewandte Chemie - International Edition
Volume41
Issue number17
DOIs
Publication statusPublished - 2 Sep 2002
Externally publishedYes

Keywords

  • Aggregation
  • Carbohydrates
  • Dendrimers
  • Polyvalence
  • Supramolecular chemistry

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