Abstract
Continuing our research efforts in developing mesoporous silicon nanoparticle-based biomaterials for cancer therapy, we employed here porous silicon nanoparticles as a nanocarrier to deliver contrast agents to diseased cells. Nanoconfinement of small molecule Gd-chelates (L1-Gd) enhanced the T1 contrast dramatically compared to distinct Gd-chelate (L1-Gd) by virtue of its slow tumbling rate, increased number of bound water molecules, and their occupancy time. The newly synthesized Gd-chelate (L1-Gd) was covalently grafted on silicon nanostructures and conjugated to an antibody specific for epidermal growth factor receptor (EGFR) via a hydrazone linkage. The salient feature of this nanosized contrast agent is the capability of EGFR targeted delivery to cancer cells. Mesoporous silicon nanoparticles were chosen as the nanocarrier because of their high porosity, high surface area, and excellent biodegradability. This type of nanosized contrast agent also performs well in high magnetic fields.
| Original language | English |
|---|---|
| Pages (from-to) | 42601-42611 |
| Number of pages | 11 |
| Journal | ACS Applied Materials and Interfaces |
| Volume | 9 |
| Issue number | 49 |
| DOIs | |
| Publication status | Published - 13 Dec 2017 |
Keywords
- EGFR
- Gd
- MRI
- porous silicon nanoparticles
- T contrast agents
Cite this
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Novel Gd-Loaded Silicon Nanohybrid : A Potential Epidermal Growth Factor Receptor Expressing Cancer Cell Targeting Magnetic Resonance Imaging Contrast Agent. / Sinha, Sougata; Tong, Wing Yin; Williamson, Nathan H.; McInnes, Steven J.P.; Puttick, Simon; Cifuentes-Rius, Anna; Bhardwaj, Richa; Plush, Sally E.; Voelcker, Nicolas H.
In: ACS Applied Materials and Interfaces, Vol. 9, No. 49, 13.12.2017, p. 42601-42611.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Novel Gd-Loaded Silicon Nanohybrid
T2 - A Potential Epidermal Growth Factor Receptor Expressing Cancer Cell Targeting Magnetic Resonance Imaging Contrast Agent
AU - Sinha, Sougata
AU - Tong, Wing Yin
AU - Williamson, Nathan H.
AU - McInnes, Steven J.P.
AU - Puttick, Simon
AU - Cifuentes-Rius, Anna
AU - Bhardwaj, Richa
AU - Plush, Sally E.
AU - Voelcker, Nicolas H.
PY - 2017/12/13
Y1 - 2017/12/13
N2 - Continuing our research efforts in developing mesoporous silicon nanoparticle-based biomaterials for cancer therapy, we employed here porous silicon nanoparticles as a nanocarrier to deliver contrast agents to diseased cells. Nanoconfinement of small molecule Gd-chelates (L1-Gd) enhanced the T1 contrast dramatically compared to distinct Gd-chelate (L1-Gd) by virtue of its slow tumbling rate, increased number of bound water molecules, and their occupancy time. The newly synthesized Gd-chelate (L1-Gd) was covalently grafted on silicon nanostructures and conjugated to an antibody specific for epidermal growth factor receptor (EGFR) via a hydrazone linkage. The salient feature of this nanosized contrast agent is the capability of EGFR targeted delivery to cancer cells. Mesoporous silicon nanoparticles were chosen as the nanocarrier because of their high porosity, high surface area, and excellent biodegradability. This type of nanosized contrast agent also performs well in high magnetic fields.
AB - Continuing our research efforts in developing mesoporous silicon nanoparticle-based biomaterials for cancer therapy, we employed here porous silicon nanoparticles as a nanocarrier to deliver contrast agents to diseased cells. Nanoconfinement of small molecule Gd-chelates (L1-Gd) enhanced the T1 contrast dramatically compared to distinct Gd-chelate (L1-Gd) by virtue of its slow tumbling rate, increased number of bound water molecules, and their occupancy time. The newly synthesized Gd-chelate (L1-Gd) was covalently grafted on silicon nanostructures and conjugated to an antibody specific for epidermal growth factor receptor (EGFR) via a hydrazone linkage. The salient feature of this nanosized contrast agent is the capability of EGFR targeted delivery to cancer cells. Mesoporous silicon nanoparticles were chosen as the nanocarrier because of their high porosity, high surface area, and excellent biodegradability. This type of nanosized contrast agent also performs well in high magnetic fields.
KW - EGFR
KW - Gd
KW - MRI
KW - porous silicon nanoparticles
KW - T contrast agents
UR - http://www.scopus.com/inward/record.url?scp=85038215756&partnerID=8YFLogxK
U2 - 10.1021/acsami.7b14538
DO - 10.1021/acsami.7b14538
M3 - Article
VL - 9
SP - 42601
EP - 42611
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
SN - 1944-8244
IS - 49
ER -