Novel cyclopeptide bolaamphiphile for constructing supramolecular nanotubes

Siyong Qin, Qingrong Wang, Yi Pei, Mengyun Peng, Renxi Zhuo, Xianzheng Zhang

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5 Citations (Scopus)


A novel dicyclopeptide-based bolaamphiphile was synthesized. The hydrophilic cyclopeptide fragments were linked to an alkyl chain 1,6-bis(maleimido)hexane, which acted as a hydrophobic spacer. The transmission electron microscopy (TEM) observation indicated that the cyclopeptide bolaamphiphile (CPB) self-assembled into the nanotubes with a thickness of about 3 nm. Based on the optimized molecular conformation obtained via MM2 method, the length of CPB was demonstrated to be around 4 nm, implying that the nanotubes were single-walled. Fourier transform infrared spectroscopy (FT-IR) and circular dichroism (CD) analysis showed that the cyclopeptides in CPB mainly acted as the hydrophilic headgroups, rather than providing the well-ordered hydrogen bonding interaction responsible for β-sheet conformation. To investigate the special self-assembly behavior of CPB, the single cyclopeptide (CP) without the connection of the linker was synthesized. Further investigation indicated that the CP molecules can not form tubular structures but nanofibers.

Original languageEnglish
Pages (from-to)22-26
Number of pages5
JournalChinese Journal of Chemistry
Issue number1
Publication statusPublished - 14 Jan 2014
Externally publishedYes


  • bolaamphiphile
  • cyclopeptide
  • nanotube
  • self-assembly

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