Novel bioabsorbable polymer and polymer-free metallic drug-eluting stents

Jason Nogic, Liam M. McCormick, Rohin Francis, Nitesh Nerlekar, Catherine Jaworski, Nick E.J. West, Adam J. Brown

Research output: Contribution to journalReview ArticleResearchpeer-review

19 Citations (Scopus)

Abstract

The introduction of drug-eluting stents (DES) significantly reduced angiographic restenosis and the clinical need for revascularization following percutaneous coronary intervention. However, concerns remain regarding the long-term safety and efficacy of DES. The use of durable polymers for drug elution that have limited biocompatibility is thought to contribute toward DES failure, by promoting an adverse local inflammatory response and vascular toxicity. Biodegradable polymer and polymer-free metallic stents represent two novel technological solutions to this challenging clinical problem. This review summarizes the available clinical evidence supporting the use of either biodegradable polymer or polymer-free DES platforms.

Original languageEnglish
Pages (from-to)435-443
Number of pages9
JournalJournal of Cardiology
Volume71
Issue number5
DOIs
Publication statusPublished - 1 May 2018

Keywords

  • Biodegradable polymer
  • Coronary artery disease
  • Drug-eluting stents
  • Percutaneous coronary intervention
  • Polymer-free

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