Novel agrochemical conjugates with self-assembling behaviour

Qingtao Liu, Bim Graham, Adrian Hawley, Yao Da Dong, Ben J. Boyd

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)


Hypothesis: That conjugation of agrichemicals to pro-assembly hydrophobic moieties will enable enhanced compatibility and loading with host lyotropic liquid crystalline carrier matrix, and potentially self-assemble in their own right in aqueous environments. Experiments: A series of lipid-like agrochemical-conjugates were synthesized using specific amphiphilic entities conjugated onto the agrochemicals, picloram and 2,4-dichlorophenoxyacetic acid (2,4-D). The self-assembly behaviour and compatibility of the novel entities when incorporated into phytantriol and monoolein-based liquid crystalline systems were examined using small angle X-ray scattering, cryo-TEM and polarized optical microscopy. Findings: Compared to agrochemical-conjugates with simple alkyl ester groups, the esterification of the agrochemicals with amphiphilic groups such as phytantriol and monoolein led to greater structural compatibility and consequently a greater loading of the agrochemicals in the liquid crystalline systems without destabilizing phase structure. Picloram-monoolein and picloram-monoelaidin can self-assemble to form lamellar structures in water. However, certain agrochemical-conjugates such as picloram-monoelaidin and picloram-PEGn-oleate showed poor compatibility with liquid crystalline systems, resulting in phase separation.

Original languageEnglish
Pages (from-to)369-378
Number of pages10
JournalJournal of Colloid and Interface Science
Publication statusPublished - 15 Feb 2018


  • Agricultural chemical
  • Lyotropic liquid crystal
  • Self assembly

Cite this