Not just a writer: PRC2 as a chromatin reader

Michael Uckelmann, Chen Davidovich

Research output: Contribution to journalReview ArticleOtherpeer-review

13 Citations (Scopus)

Abstract

PRC2 deposits the H3K27me3 repressive mark, which facilitates transcription repression of developmental genes. The decision of whether a particular gene is silenced at a given point during development is heavily dependent on the chromatin context. More than just a simple epigenetic writer, PRC2 employs several distinct chromatin reading capabilities to sense the local chromatin environment and modulate the H3K27me3 writer activity in a context-dependent manner. Here we discuss the complex interplay of PRC2 with the hallmarks of active and repressive chromatin, how it affects H3K27me3 deposition and how it guides transcriptional activity.

Original languageEnglish
Pages (from-to)1159-1170
Number of pages12
JournalBiochemical Society Transactions
Volume49
Issue number3
DOIs
Publication statusPublished - Jun 2021

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