Norovirus Infection: Replication, Manipulation of Host, and Interaction with the Host Immune Response

Soroush T. Sarvestani; Ben Cotton; Svenja Fritzlar; Tanya B. O'Donnell; Jason M. MacKenzie

doi:10.1089/jir.2015.0124

Norovirus Infection: Replication, Manipulation of Host, and Interaction with the Host Immune Response

Soroush T. Sarvestani, Ben Cotton, Svenja Fritzlar, Tanya B. O'Donnell, Jason M. MacKenzie

Research output: Contribution to journal › Review Article › Research › peer-review

8 Citations (Scopus)

Abstract

Noroviruses (NoVs) belong to the Caliciviridae family of viruses and are responsible for causing the majority of gastroenteritis outbreaks worldwide. In the past decade, research on NoV biology has intensified because of the discovery of murine NoV and subsequently the first cell culture system and small animal model for NoV replication and pathogenesis. In this review, we discuss the current literature on NoV biology, focusing particularly on NoV replication and the interaction between NoV and the host immune response. Understanding the NoV replication cycle and its interaction with cellular processes and innate immune immunity will help develop molecular targets to control human NoV infection and prevent outbreaks. In addition to the innate immune response, we have documented the current efforts to develop NoV vaccines to control outbreaks.

Original language	English
Pages (from-to)	215-225
Number of pages	11
Journal	Journal of Interferon and Cytokine Research
Volume	36
Issue number	4
DOIs	https://doi.org/10.1089/jir.2015.0124
Publication status	Published - 1 Apr 2016
Externally published	Yes

Access to Document

10.1089/jir.2015.0124

Link to publication in Scopus

Cite this

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title = "Norovirus Infection: Replication, Manipulation of Host, and Interaction with the Host Immune Response",

abstract = "Noroviruses (NoVs) belong to the Caliciviridae family of viruses and are responsible for causing the majority of gastroenteritis outbreaks worldwide. In the past decade, research on NoV biology has intensified because of the discovery of murine NoV and subsequently the first cell culture system and small animal model for NoV replication and pathogenesis. In this review, we discuss the current literature on NoV biology, focusing particularly on NoV replication and the interaction between NoV and the host immune response. Understanding the NoV replication cycle and its interaction with cellular processes and innate immune immunity will help develop molecular targets to control human NoV infection and prevent outbreaks. In addition to the innate immune response, we have documented the current efforts to develop NoV vaccines to control outbreaks.",

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Norovirus Infection : Replication, Manipulation of Host, and Interaction with the Host Immune Response. / Sarvestani, Soroush T.; Cotton, Ben; Fritzlar, Svenja; O'Donnell, Tanya B.; MacKenzie, Jason M.

In: Journal of Interferon and Cytokine Research, Vol. 36, No. 4, 01.04.2016, p. 215-225.

Research output: Contribution to journal › Review Article › Research › peer-review

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T1 - Norovirus Infection

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AU - Sarvestani, Soroush T.

AU - Cotton, Ben

AU - Fritzlar, Svenja

AU - O'Donnell, Tanya B.

AU - MacKenzie, Jason M.

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AB - Noroviruses (NoVs) belong to the Caliciviridae family of viruses and are responsible for causing the majority of gastroenteritis outbreaks worldwide. In the past decade, research on NoV biology has intensified because of the discovery of murine NoV and subsequently the first cell culture system and small animal model for NoV replication and pathogenesis. In this review, we discuss the current literature on NoV biology, focusing particularly on NoV replication and the interaction between NoV and the host immune response. Understanding the NoV replication cycle and its interaction with cellular processes and innate immune immunity will help develop molecular targets to control human NoV infection and prevent outbreaks. In addition to the innate immune response, we have documented the current efforts to develop NoV vaccines to control outbreaks.

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