Norovirus Infection: Replication, Manipulation of Host, and Interaction with the Host Immune Response

Soroush T. Sarvestani, Ben Cotton, Svenja Fritzlar, Tanya B. O'Donnell, Jason M. MacKenzie

Research output: Contribution to journalReview ArticleResearchpeer-review

12 Citations (Scopus)


Noroviruses (NoVs) belong to the Caliciviridae family of viruses and are responsible for causing the majority of gastroenteritis outbreaks worldwide. In the past decade, research on NoV biology has intensified because of the discovery of murine NoV and subsequently the first cell culture system and small animal model for NoV replication and pathogenesis. In this review, we discuss the current literature on NoV biology, focusing particularly on NoV replication and the interaction between NoV and the host immune response. Understanding the NoV replication cycle and its interaction with cellular processes and innate immune immunity will help develop molecular targets to control human NoV infection and prevent outbreaks. In addition to the innate immune response, we have documented the current efforts to develop NoV vaccines to control outbreaks.

Original languageEnglish
Pages (from-to)215-225
Number of pages11
JournalJournal of Interferon and Cytokine Research
Issue number4
Publication statusPublished - 1 Apr 2016
Externally publishedYes

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