Abstract

Aims
The worldwide prevalence of gestational diabetes mellitus (GDM) is increasing. Studies in rodent models indicate that hyperglycaemia during pregnancy alters kidney development, yet few studies have examined if this is so in humans. The objective of this study was to evaluate the association of treated GDM with foetal kidney size.
Materials and Methods
Participants were recruited from an Australian tertiary hospital, and clinical data were collected from women without GDM and women diagnosed and treated for GDM and their offspring. Participants underwent an obstetric ultrasound at 32‐34 weeks gestation for foetal biometry and foetal kidney volume measurement.
Results
Sixty‐four non‐GDM and 64 GDM women participated in the study. Thirty percent of GDM women were diagnosed with fasting hyperglycaemia, while 89% had an elevated 2‐hour glucose level. Maternal age, weight and body mass index were similar in women with and without GDM. Estimated foetal weight, foetal kidney dimensions, total foetal kidney volume and birth weight were similar in offspring of women with and without GDM.
Conclusions
We conclude that a period of mild hyperglycaemia prior to diagnosis of GDM and treatment initiation, which coincides with a period of rapid nephron formation and kidney growth, does not alter kidney size at 32‐34 weeks gestation.
Original languageEnglish
Article numbere00091
Number of pages9
JournalEndocrinology, Diabetes & Metabolism
Volume2
Issue number4
DOIs
Publication statusPublished - Oct 2019

Keywords

  • foetal kidney volume
  • gestational diabetes
  • kidney development

Cite this

@article{5f7ca777fce54788994f8441b553cee2,
title = "Normal foetal kidney volume in offspring of women treated for gestational diabetes",
abstract = "AimsThe worldwide prevalence of gestational diabetes mellitus (GDM) is increasing. Studies in rodent models indicate that hyperglycaemia during pregnancy alters kidney development, yet few studies have examined if this is so in humans. The objective of this study was to evaluate the association of treated GDM with foetal kidney size.Materials and MethodsParticipants were recruited from an Australian tertiary hospital, and clinical data were collected from women without GDM and women diagnosed and treated for GDM and their offspring. Participants underwent an obstetric ultrasound at 32‐34 weeks gestation for foetal biometry and foetal kidney volume measurement.ResultsSixty‐four non‐GDM and 64 GDM women participated in the study. Thirty percent of GDM women were diagnosed with fasting hyperglycaemia, while 89{\%} had an elevated 2‐hour glucose level. Maternal age, weight and body mass index were similar in women with and without GDM. Estimated foetal weight, foetal kidney dimensions, total foetal kidney volume and birth weight were similar in offspring of women with and without GDM.ConclusionsWe conclude that a period of mild hyperglycaemia prior to diagnosis of GDM and treatment initiation, which coincides with a period of rapid nephron formation and kidney growth, does not alter kidney size at 32‐34 weeks gestation.",
keywords = "foetal kidney volume, gestational diabetes, kidney development",
author = "Stacey Hokke and {De Zoysa}, Natasha and Carr, {Bethany L.} and Veronica Abruzzo and Coombs, {Peter R.} and Allan, {Carolyn A.} and Christine East and Julie Ingelfinger and Puelles, {Victor G.} and Black, {Mary J.} and Danica Ryan and Armitage, {James A.} and Wallace, {Euan M.} and Bertram, {John F.} and Cullen-McEwen, {Luise A.}",
year = "2019",
month = "10",
doi = "10.1002/edm2.91",
language = "English",
volume = "2",
journal = "Endocrinology, Diabetes & Metabolism",
issn = "2398-9238",
publisher = "John Wiley & Sons",
number = "4",

}

Normal foetal kidney volume in offspring of women treated for gestational diabetes. / Hokke, Stacey; De Zoysa, Natasha; Carr, Bethany L.; Abruzzo, Veronica; Coombs, Peter R.; Allan, Carolyn A.; East, Christine; Ingelfinger, Julie; Puelles, Victor G.; Black, Mary J.; Ryan, Danica; Armitage, James A.; Wallace, Euan M.; Bertram, John F.; Cullen-McEwen, Luise A.

In: Endocrinology, Diabetes & Metabolism, Vol. 2, No. 4, e00091, 10.2019.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Normal foetal kidney volume in offspring of women treated for gestational diabetes

AU - Hokke, Stacey

AU - De Zoysa, Natasha

AU - Carr, Bethany L.

AU - Abruzzo, Veronica

AU - Coombs, Peter R.

AU - Allan, Carolyn A.

AU - East, Christine

AU - Ingelfinger, Julie

AU - Puelles, Victor G.

AU - Black, Mary J.

AU - Ryan, Danica

AU - Armitage, James A.

AU - Wallace, Euan M.

AU - Bertram, John F.

AU - Cullen-McEwen, Luise A.

PY - 2019/10

Y1 - 2019/10

N2 - AimsThe worldwide prevalence of gestational diabetes mellitus (GDM) is increasing. Studies in rodent models indicate that hyperglycaemia during pregnancy alters kidney development, yet few studies have examined if this is so in humans. The objective of this study was to evaluate the association of treated GDM with foetal kidney size.Materials and MethodsParticipants were recruited from an Australian tertiary hospital, and clinical data were collected from women without GDM and women diagnosed and treated for GDM and their offspring. Participants underwent an obstetric ultrasound at 32‐34 weeks gestation for foetal biometry and foetal kidney volume measurement.ResultsSixty‐four non‐GDM and 64 GDM women participated in the study. Thirty percent of GDM women were diagnosed with fasting hyperglycaemia, while 89% had an elevated 2‐hour glucose level. Maternal age, weight and body mass index were similar in women with and without GDM. Estimated foetal weight, foetal kidney dimensions, total foetal kidney volume and birth weight were similar in offspring of women with and without GDM.ConclusionsWe conclude that a period of mild hyperglycaemia prior to diagnosis of GDM and treatment initiation, which coincides with a period of rapid nephron formation and kidney growth, does not alter kidney size at 32‐34 weeks gestation.

AB - AimsThe worldwide prevalence of gestational diabetes mellitus (GDM) is increasing. Studies in rodent models indicate that hyperglycaemia during pregnancy alters kidney development, yet few studies have examined if this is so in humans. The objective of this study was to evaluate the association of treated GDM with foetal kidney size.Materials and MethodsParticipants were recruited from an Australian tertiary hospital, and clinical data were collected from women without GDM and women diagnosed and treated for GDM and their offspring. Participants underwent an obstetric ultrasound at 32‐34 weeks gestation for foetal biometry and foetal kidney volume measurement.ResultsSixty‐four non‐GDM and 64 GDM women participated in the study. Thirty percent of GDM women were diagnosed with fasting hyperglycaemia, while 89% had an elevated 2‐hour glucose level. Maternal age, weight and body mass index were similar in women with and without GDM. Estimated foetal weight, foetal kidney dimensions, total foetal kidney volume and birth weight were similar in offspring of women with and without GDM.ConclusionsWe conclude that a period of mild hyperglycaemia prior to diagnosis of GDM and treatment initiation, which coincides with a period of rapid nephron formation and kidney growth, does not alter kidney size at 32‐34 weeks gestation.

KW - foetal kidney volume

KW - gestational diabetes

KW - kidney development

U2 - 10.1002/edm2.91

DO - 10.1002/edm2.91

M3 - Article

VL - 2

JO - Endocrinology, Diabetes & Metabolism

JF - Endocrinology, Diabetes & Metabolism

SN - 2398-9238

IS - 4

M1 - e00091

ER -