Normal brain metabolism on FDG PET/MRI during childhood and adolescence

Thomas W. Barber, Duncan Veysey, Baki Billah, Peter Francis

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective The aim was to investigate normal patterns of brain metabolism determined by 18F-fluorodeoxyglucose positron emission tomography (FDG PET)/MRI during childhood and adolescence. Patients and methods A retrospective analysis was carried out on all paediatric patients who underwent FDG PET/MRI at our institution between March 2016 and August 2017. Exclusion criteria were neurological disease, central nervous system metastases, previous chemotherapy/ radiotherapy, general anaesthesia/sedation and medications suspected to affect cerebral metabolism. Standardized uptake value (SUV)mean and SUVmax were calculated for 12 brain grey matter regions. Subgroup analysis of childhood (≤ 10 years old) and adolescence (≥11 years old) was also carried out. Results From 492 PET/MRI scans, 28 patients (11 children, 17 adolescents) were deemed representative of normal brain metabolism. SUVmean and SUVmax increased with age in all regions. The highest rates of increasing SUVmean were in the thalamus, basal ganglia, frontal lobes, insula and occipital lobes. Higher SUVmean was found in the right frontal, right lateral temporal, right temporal pole, right cingulate/paracingulate, right thalamus, left occipital, left basal ganglia, left insula and left cerebellum compared with the contralateral side. This SUVmean asymmetry was present in both childhood and adolescence in the majority of regions. The highest rates of increasing SUVmax with age were in the occipital lobes, frontal lobes, thalamus and central region. There was no asymmetry in SUVmax in the majority of regions. Conclusion This FDG PET/MRI study shows that normal brain metabolism measured by SUVmean and SUVmax increases with age in all regions, proceeding at different rates between distinct anatomical sites. Our results suggest that there is mild asymmetry in SUVmean, but mostly symmetric SUVmax during normal development.

Original languageEnglish
Pages (from-to)1022-1032
Number of pages11
JournalNuclear Medicine Communications
Volume39
Issue number11
DOIs
Publication statusPublished - Nov 2018

Keywords

  • Brain
  • Child
  • Magnetic resonance imaging
  • Positron emission tomography

Cite this

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title = "Normal brain metabolism on FDG PET/MRI during childhood and adolescence",
abstract = "Objective The aim was to investigate normal patterns of brain metabolism determined by 18F-fluorodeoxyglucose positron emission tomography (FDG PET)/MRI during childhood and adolescence. Patients and methods A retrospective analysis was carried out on all paediatric patients who underwent FDG PET/MRI at our institution between March 2016 and August 2017. Exclusion criteria were neurological disease, central nervous system metastases, previous chemotherapy/ radiotherapy, general anaesthesia/sedation and medications suspected to affect cerebral metabolism. Standardized uptake value (SUV)mean and SUVmax were calculated for 12 brain grey matter regions. Subgroup analysis of childhood (≤ 10 years old) and adolescence (≥11 years old) was also carried out. Results From 492 PET/MRI scans, 28 patients (11 children, 17 adolescents) were deemed representative of normal brain metabolism. SUVmean and SUVmax increased with age in all regions. The highest rates of increasing SUVmean were in the thalamus, basal ganglia, frontal lobes, insula and occipital lobes. Higher SUVmean was found in the right frontal, right lateral temporal, right temporal pole, right cingulate/paracingulate, right thalamus, left occipital, left basal ganglia, left insula and left cerebellum compared with the contralateral side. This SUVmean asymmetry was present in both childhood and adolescence in the majority of regions. The highest rates of increasing SUVmax with age were in the occipital lobes, frontal lobes, thalamus and central region. There was no asymmetry in SUVmax in the majority of regions. Conclusion This FDG PET/MRI study shows that normal brain metabolism measured by SUVmean and SUVmax increases with age in all regions, proceeding at different rates between distinct anatomical sites. Our results suggest that there is mild asymmetry in SUVmean, but mostly symmetric SUVmax during normal development.",
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Normal brain metabolism on FDG PET/MRI during childhood and adolescence. / Barber, Thomas W.; Veysey, Duncan; Billah, Baki; Francis, Peter.

In: Nuclear Medicine Communications, Vol. 39, No. 11, 11.2018, p. 1022-1032.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Normal brain metabolism on FDG PET/MRI during childhood and adolescence

AU - Barber, Thomas W.

AU - Veysey, Duncan

AU - Billah, Baki

AU - Francis, Peter

PY - 2018/11

Y1 - 2018/11

N2 - Objective The aim was to investigate normal patterns of brain metabolism determined by 18F-fluorodeoxyglucose positron emission tomography (FDG PET)/MRI during childhood and adolescence. Patients and methods A retrospective analysis was carried out on all paediatric patients who underwent FDG PET/MRI at our institution between March 2016 and August 2017. Exclusion criteria were neurological disease, central nervous system metastases, previous chemotherapy/ radiotherapy, general anaesthesia/sedation and medications suspected to affect cerebral metabolism. Standardized uptake value (SUV)mean and SUVmax were calculated for 12 brain grey matter regions. Subgroup analysis of childhood (≤ 10 years old) and adolescence (≥11 years old) was also carried out. Results From 492 PET/MRI scans, 28 patients (11 children, 17 adolescents) were deemed representative of normal brain metabolism. SUVmean and SUVmax increased with age in all regions. The highest rates of increasing SUVmean were in the thalamus, basal ganglia, frontal lobes, insula and occipital lobes. Higher SUVmean was found in the right frontal, right lateral temporal, right temporal pole, right cingulate/paracingulate, right thalamus, left occipital, left basal ganglia, left insula and left cerebellum compared with the contralateral side. This SUVmean asymmetry was present in both childhood and adolescence in the majority of regions. The highest rates of increasing SUVmax with age were in the occipital lobes, frontal lobes, thalamus and central region. There was no asymmetry in SUVmax in the majority of regions. Conclusion This FDG PET/MRI study shows that normal brain metabolism measured by SUVmean and SUVmax increases with age in all regions, proceeding at different rates between distinct anatomical sites. Our results suggest that there is mild asymmetry in SUVmean, but mostly symmetric SUVmax during normal development.

AB - Objective The aim was to investigate normal patterns of brain metabolism determined by 18F-fluorodeoxyglucose positron emission tomography (FDG PET)/MRI during childhood and adolescence. Patients and methods A retrospective analysis was carried out on all paediatric patients who underwent FDG PET/MRI at our institution between March 2016 and August 2017. Exclusion criteria were neurological disease, central nervous system metastases, previous chemotherapy/ radiotherapy, general anaesthesia/sedation and medications suspected to affect cerebral metabolism. Standardized uptake value (SUV)mean and SUVmax were calculated for 12 brain grey matter regions. Subgroup analysis of childhood (≤ 10 years old) and adolescence (≥11 years old) was also carried out. Results From 492 PET/MRI scans, 28 patients (11 children, 17 adolescents) were deemed representative of normal brain metabolism. SUVmean and SUVmax increased with age in all regions. The highest rates of increasing SUVmean were in the thalamus, basal ganglia, frontal lobes, insula and occipital lobes. Higher SUVmean was found in the right frontal, right lateral temporal, right temporal pole, right cingulate/paracingulate, right thalamus, left occipital, left basal ganglia, left insula and left cerebellum compared with the contralateral side. This SUVmean asymmetry was present in both childhood and adolescence in the majority of regions. The highest rates of increasing SUVmax with age were in the occipital lobes, frontal lobes, thalamus and central region. There was no asymmetry in SUVmax in the majority of regions. Conclusion This FDG PET/MRI study shows that normal brain metabolism measured by SUVmean and SUVmax increases with age in all regions, proceeding at different rates between distinct anatomical sites. Our results suggest that there is mild asymmetry in SUVmean, but mostly symmetric SUVmax during normal development.

KW - Brain

KW - Child

KW - Magnetic resonance imaging

KW - Positron emission tomography

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U2 - 10.1097/MNM.0000000000000912

DO - 10.1097/MNM.0000000000000912

M3 - Article

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SP - 1022

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JF - Nuclear Medicine Communications

SN - 0143-3636

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