Norfloxacin treatment for clinically significant portal hypertension: results of a randomised double-blind placebo-controlled crossover trial

William Wilson Kemp; John Colman; Kenneth Thompson; Anoop Madan; Margaret Vincent; Jaye PF Chin-Dusting; Andrew Richard Kompa; Henry Krum; Stuart Roberts

doi:10.1111/j.1478-3231.2008.01850.x

Norfloxacin treatment for clinically significant portal hypertension: results of a randomised double-blind placebo-controlled crossover trial

William Wilson Kemp, John Colman, Kenneth Thompson, Anoop Madan, Margaret Vincent, Jaye PF Chin-Dusting, Andrew Richard Kompa, Henry Krum, Stuart Roberts

Epidemiology and Preventive Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

26 Citations (Scopus)

Abstract

While selective intestinal decontamination (SID) can alter the hyperdynamic circulatory state of cirrhosis, the impact of SID on portal pressure remains unclear especially in the setting of clinically significant portal hypertension. Aims: To examine the impact of SID with norfloxacin on portal pressure in subjects with clinically significant portal hypertension and explore the potential mechanisms by which norfloxacin exerts its haemodynamic effects

Original language	English
Pages (from-to)	427 - 433
Number of pages	7
Journal	Liver International
Volume	29
Issue number	3
DOIs	https://doi.org/10.1111/j.1478-3231.2008.01850.x
Publication status	Published - 2009

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10.1111/j.1478-3231.2008.01850.x

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Cite this

Kemp, William Wilson ; Colman, John ; Thompson, Kenneth ; Madan, Anoop ; Vincent, Margaret ; Chin-Dusting, Jaye PF ; Kompa, Andrew Richard ; Krum, Henry ; Roberts, Stuart. / Norfloxacin treatment for clinically significant portal hypertension: results of a randomised double-blind placebo-controlled crossover trial. In: Liver International. 2009 ; Vol. 29, No. 3. pp. 427 - 433.

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abstract = "While selective intestinal decontamination (SID) can alter the hyperdynamic circulatory state of cirrhosis, the impact of SID on portal pressure remains unclear especially in the setting of clinically significant portal hypertension. Aims: To examine the impact of SID with norfloxacin on portal pressure in subjects with clinically significant portal hypertension and explore the potential mechanisms by which norfloxacin exerts its haemodynamic effects",

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Norfloxacin treatment for clinically significant portal hypertension: results of a randomised double-blind placebo-controlled crossover trial. / Kemp, William Wilson; Colman, John; Thompson, Kenneth; Madan, Anoop; Vincent, Margaret; Chin-Dusting, Jaye PF; Kompa, Andrew Richard; Krum, Henry; Roberts, Stuart.

In: Liver International, Vol. 29, No. 3, 2009, p. 427 - 433.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Thompson, Kenneth

AU - Madan, Anoop

AU - Vincent, Margaret

AU - Chin-Dusting, Jaye PF

AU - Kompa, Andrew Richard

AU - Krum, Henry

AU - Roberts, Stuart

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AB - While selective intestinal decontamination (SID) can alter the hyperdynamic circulatory state of cirrhosis, the impact of SID on portal pressure remains unclear especially in the setting of clinically significant portal hypertension. Aims: To examine the impact of SID with norfloxacin on portal pressure in subjects with clinically significant portal hypertension and explore the potential mechanisms by which norfloxacin exerts its haemodynamic effects

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DO - 10.1111/j.1478-3231.2008.01850.x

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EP - 433

JO - Liver International

JF - Liver International

SN - 1478-3223

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