Norepinephrine genes predict response time variability and methylphenidate-induced changes in neuropsychological function in attention deficit hyperactivity disorder

Bung-Nyun Kim, Jae-Won Kim, Tarrant Dumas Cummins, Mark Andrew Bellgrove, Ziarih Hawi, Soon Beom Hong, Young Hui Yang, Hyo Jin Kim, Min Sup Shin, Soo-Churl Cho, Ji Hoon Kim, Jung Woo Son, Yun Mi Shin, Un Sun Chung, Doug Hyun Han

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Abstract

Noradrenergic dysfunction may be associated with cognitive impairments in attention-deficit/hyperactivity disorder (ADHD), including increased response time variability, which has been proposed as a leading endophenotype for ADHD. The aim of this study was to examine the relationship between polymorphisms in the a-2A-adrenergic receptor (ADRA2A) and norepinephrine transporter (SLC6A2) genes and attentional performance in ADHD children before and after pharmacological treatment.
Original languageEnglish
Pages (from-to)356 - 362
Number of pages7
JournalJournal of Clinical Psychopharmacology
Volume33
Issue number3
DOIs
Publication statusPublished - 2013

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