Norepinephrine genes predict response time variability and methylphenidate-induced changes in neuropsychological function in attention deficit hyperactivity disorder

Bung-Nyun Kim, Jae-Won Kim, Tarrant Dumas Cummins, Mark Andrew Bellgrove, Ziarih Hawi, Soon Beom Hong, Young Hui Yang, Hyo Jin Kim, Min Sup Shin, Soo-Churl Cho, Ji Hoon Kim, Jung Woo Son, Yun Mi Shin, Un Sun Chung, Doug Hyun Han

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Abstract

Noradrenergic dysfunction may be associated with cognitive impairments in attention-deficit/hyperactivity disorder (ADHD), including increased response time variability, which has been proposed as a leading endophenotype for ADHD. The aim of this study was to examine the relationship between polymorphisms in the a-2A-adrenergic receptor (ADRA2A) and norepinephrine transporter (SLC6A2) genes and attentional performance in ADHD children before and after pharmacological treatment.
Original languageEnglish
Pages (from-to)356 - 362
Number of pages7
JournalJournal of Clinical Psychopharmacology
Volume33
Issue number3
DOIs
Publication statusPublished - 2013

Cite this

Kim, Bung-Nyun ; Kim, Jae-Won ; Cummins, Tarrant Dumas ; Bellgrove, Mark Andrew ; Hawi, Ziarih ; Hong, Soon Beom ; Yang, Young Hui ; Kim, Hyo Jin ; Shin, Min Sup ; Cho, Soo-Churl ; Kim, Ji Hoon ; Son, Jung Woo ; Shin, Yun Mi ; Chung, Un Sun ; Han, Doug Hyun. / Norepinephrine genes predict response time variability and methylphenidate-induced changes in neuropsychological function in attention deficit hyperactivity disorder. In: Journal of Clinical Psychopharmacology. 2013 ; Vol. 33, No. 3. pp. 356 - 362.
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abstract = "Noradrenergic dysfunction may be associated with cognitive impairments in attention-deficit/hyperactivity disorder (ADHD), including increased response time variability, which has been proposed as a leading endophenotype for ADHD. The aim of this study was to examine the relationship between polymorphisms in the a-2A-adrenergic receptor (ADRA2A) and norepinephrine transporter (SLC6A2) genes and attentional performance in ADHD children before and after pharmacological treatment.",
author = "Bung-Nyun Kim and Jae-Won Kim and Cummins, {Tarrant Dumas} and Bellgrove, {Mark Andrew} and Ziarih Hawi and Hong, {Soon Beom} and Yang, {Young Hui} and Kim, {Hyo Jin} and Shin, {Min Sup} and Soo-Churl Cho and Kim, {Ji Hoon} and Son, {Jung Woo} and Shin, {Yun Mi} and Chung, {Un Sun} and Han, {Doug Hyun}",
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Norepinephrine genes predict response time variability and methylphenidate-induced changes in neuropsychological function in attention deficit hyperactivity disorder. / Kim, Bung-Nyun; Kim, Jae-Won; Cummins, Tarrant Dumas; Bellgrove, Mark Andrew; Hawi, Ziarih; Hong, Soon Beom; Yang, Young Hui; Kim, Hyo Jin; Shin, Min Sup; Cho, Soo-Churl; Kim, Ji Hoon; Son, Jung Woo; Shin, Yun Mi; Chung, Un Sun; Han, Doug Hyun.

In: Journal of Clinical Psychopharmacology, Vol. 33, No. 3, 2013, p. 356 - 362.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Norepinephrine genes predict response time variability and methylphenidate-induced changes in neuropsychological function in attention deficit hyperactivity disorder

AU - Kim, Bung-Nyun

AU - Kim, Jae-Won

AU - Cummins, Tarrant Dumas

AU - Bellgrove, Mark Andrew

AU - Hawi, Ziarih

AU - Hong, Soon Beom

AU - Yang, Young Hui

AU - Kim, Hyo Jin

AU - Shin, Min Sup

AU - Cho, Soo-Churl

AU - Kim, Ji Hoon

AU - Son, Jung Woo

AU - Shin, Yun Mi

AU - Chung, Un Sun

AU - Han, Doug Hyun

PY - 2013

Y1 - 2013

N2 - Noradrenergic dysfunction may be associated with cognitive impairments in attention-deficit/hyperactivity disorder (ADHD), including increased response time variability, which has been proposed as a leading endophenotype for ADHD. The aim of this study was to examine the relationship between polymorphisms in the a-2A-adrenergic receptor (ADRA2A) and norepinephrine transporter (SLC6A2) genes and attentional performance in ADHD children before and after pharmacological treatment.

AB - Noradrenergic dysfunction may be associated with cognitive impairments in attention-deficit/hyperactivity disorder (ADHD), including increased response time variability, which has been proposed as a leading endophenotype for ADHD. The aim of this study was to examine the relationship between polymorphisms in the a-2A-adrenergic receptor (ADRA2A) and norepinephrine transporter (SLC6A2) genes and attentional performance in ADHD children before and after pharmacological treatment.

UR - http://www.ncbi.nlm.nih.gov/pubmed/23609393

U2 - 10.1097/JCP.0b013e31828f9fc3

DO - 10.1097/JCP.0b013e31828f9fc3

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JO - Journal of Clinical Psychopharmacology

JF - Journal of Clinical Psychopharmacology

SN - 0271-0749

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ER -