Norepinephrine genes predict response time variability and methylphenidate-induced changes in neuropsychological function in attention deficit hyperactivity disorder

Bung-Nyun Kim; Jae-Won Kim; Tarrant Dumas Cummins; Mark Andrew Bellgrove; Ziarih Hawi; Soon Beom Hong; Young Hui Yang; Hyo Jin Kim; Min Sup Shin; Soo-Churl Cho; Ji Hoon Kim; Jung Woo Son; Yun Mi Shin; Un Sun Chung; Doug Hyun Han

doi:10.1097/JCP.0b013e31828f9fc3

Norepinephrine genes predict response time variability and methylphenidate-induced changes in neuropsychological function in attention deficit hyperactivity disorder

Bung-Nyun Kim, Jae-Won Kim, Tarrant Dumas Cummins, Mark Andrew Bellgrove, Ziarih Hawi, Soon Beom Hong, Young Hui Yang, Hyo Jin Kim, Min Sup Shin, Soo-Churl Cho, Ji Hoon Kim, Jung Woo Son, Yun Mi Shin, Un Sun Chung, Doug Hyun Han

Psychology

Research output: Contribution to journal › Article › Research › peer-review

20 Citations (Scopus)

Abstract

Noradrenergic dysfunction may be associated with cognitive impairments in attention-deficit/hyperactivity disorder (ADHD), including increased response time variability, which has been proposed as a leading endophenotype for ADHD. The aim of this study was to examine the relationship between polymorphisms in the a-2A-adrenergic receptor (ADRA2A) and norepinephrine transporter (SLC6A2) genes and attentional performance in ADHD children before and after pharmacological treatment.

Original language	English
Pages (from-to)	356 - 362
Number of pages	7
Journal	Journal of Clinical Psychopharmacology
Volume	33
Issue number	3
DOIs	https://doi.org/10.1097/JCP.0b013e31828f9fc3
Publication status	Published - 2013

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10.1097/JCP.0b013e31828f9fc3

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Kim, B-N., Kim, J-W., Cummins, T. D., Bellgrove, M. A., Hawi, Z., Hong, S. B., Yang, Y. H., Kim, H. J., Shin, M. S., Cho, S-C., Kim, J. H., Son, J. W., Shin, Y. M., Chung, U. S., & Han, D. H. (2013). Norepinephrine genes predict response time variability and methylphenidate-induced changes in neuropsychological function in attention deficit hyperactivity disorder. Journal of Clinical Psychopharmacology, 33(3), 356 - 362. https://doi.org/10.1097/JCP.0b013e31828f9fc3

Kim, Bung-Nyun ; Kim, Jae-Won ; Cummins, Tarrant Dumas ; Bellgrove, Mark Andrew ; Hawi, Ziarih ; Hong, Soon Beom ; Yang, Young Hui ; Kim, Hyo Jin ; Shin, Min Sup ; Cho, Soo-Churl ; Kim, Ji Hoon ; Son, Jung Woo ; Shin, Yun Mi ; Chung, Un Sun ; Han, Doug Hyun. / Norepinephrine genes predict response time variability and methylphenidate-induced changes in neuropsychological function in attention deficit hyperactivity disorder. In: Journal of Clinical Psychopharmacology. 2013 ; Vol. 33, No. 3. pp. 356 - 362.

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title = "Norepinephrine genes predict response time variability and methylphenidate-induced changes in neuropsychological function in attention deficit hyperactivity disorder",

abstract = "Noradrenergic dysfunction may be associated with cognitive impairments in attention-deficit/hyperactivity disorder (ADHD), including increased response time variability, which has been proposed as a leading endophenotype for ADHD. The aim of this study was to examine the relationship between polymorphisms in the a-2A-adrenergic receptor (ADRA2A) and norepinephrine transporter (SLC6A2) genes and attentional performance in ADHD children before and after pharmacological treatment.",

author = "Bung-Nyun Kim and Jae-Won Kim and Cummins, {Tarrant Dumas} and Bellgrove, {Mark Andrew} and Ziarih Hawi and Hong, {Soon Beom} and Yang, {Young Hui} and Kim, {Hyo Jin} and Shin, {Min Sup} and Soo-Churl Cho and Kim, {Ji Hoon} and Son, {Jung Woo} and Shin, {Yun Mi} and Chung, {Un Sun} and Han, {Doug Hyun}",

year = "2013",

doi = "10.1097/JCP.0b013e31828f9fc3",

language = "English",

volume = "33",

pages = "356 -- 362",

journal = "Journal of Clinical Psychopharmacology",

issn = "0271-0749",

publisher = "Lippincott Williams & Wilkins",

number = "3",

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Kim, B-N, Kim, J-W, Cummins, TD, Bellgrove, MA , Hawi, Z, Hong, SB, Yang, YH, Kim, HJ, Shin, MS, Cho, S-C, Kim, JH, Son, JW, Shin, YM, Chung, US & Han, DH 2013, 'Norepinephrine genes predict response time variability and methylphenidate-induced changes in neuropsychological function in attention deficit hyperactivity disorder', Journal of Clinical Psychopharmacology, vol. 33, no. 3, pp. 356 - 362. https://doi.org/10.1097/JCP.0b013e31828f9fc3

Norepinephrine genes predict response time variability and methylphenidate-induced changes in neuropsychological function in attention deficit hyperactivity disorder. / Kim, Bung-Nyun; Kim, Jae-Won; Cummins, Tarrant Dumas; Bellgrove, Mark Andrew ; Hawi, Ziarih; Hong, Soon Beom; Yang, Young Hui; Kim, Hyo Jin; Shin, Min Sup; Cho, Soo-Churl; Kim, Ji Hoon; Son, Jung Woo; Shin, Yun Mi; Chung, Un Sun; Han, Doug Hyun.

In: Journal of Clinical Psychopharmacology, Vol. 33, No. 3, 2013, p. 356 - 362.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Norepinephrine genes predict response time variability and methylphenidate-induced changes in neuropsychological function in attention deficit hyperactivity disorder

AU - Kim, Bung-Nyun

AU - Kim, Jae-Won

AU - Cummins, Tarrant Dumas

AU - Bellgrove, Mark Andrew

AU - Hawi, Ziarih

AU - Hong, Soon Beom

AU - Yang, Young Hui

AU - Kim, Hyo Jin

AU - Shin, Min Sup

AU - Cho, Soo-Churl

AU - Kim, Ji Hoon

AU - Son, Jung Woo

AU - Shin, Yun Mi

AU - Chung, Un Sun

AU - Han, Doug Hyun

PY - 2013

Y1 - 2013

N2 - Noradrenergic dysfunction may be associated with cognitive impairments in attention-deficit/hyperactivity disorder (ADHD), including increased response time variability, which has been proposed as a leading endophenotype for ADHD. The aim of this study was to examine the relationship between polymorphisms in the a-2A-adrenergic receptor (ADRA2A) and norepinephrine transporter (SLC6A2) genes and attentional performance in ADHD children before and after pharmacological treatment.

AB - Noradrenergic dysfunction may be associated with cognitive impairments in attention-deficit/hyperactivity disorder (ADHD), including increased response time variability, which has been proposed as a leading endophenotype for ADHD. The aim of this study was to examine the relationship between polymorphisms in the a-2A-adrenergic receptor (ADRA2A) and norepinephrine transporter (SLC6A2) genes and attentional performance in ADHD children before and after pharmacological treatment.

UR - http://www.ncbi.nlm.nih.gov/pubmed/23609393

U2 - 10.1097/JCP.0b013e31828f9fc3

DO - 10.1097/JCP.0b013e31828f9fc3

M3 - Article

VL - 33

SP - 356

EP - 362

JO - Journal of Clinical Psychopharmacology

JF - Journal of Clinical Psychopharmacology

SN - 0271-0749

IS - 3

ER -

Norepinephrine genes predict response time variability and methylphenidate-induced changes in neuropsychological function in attention deficit hyperactivity disorder

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Functional characterisation of genetic risk variants for ADHD: from Association to Biology

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Norepinephrine genes predict response time variability and methylphenidate-induced changes in neuropsychological function in attention deficit hyperactivity disorder

Abstract

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Functional characterisation of genetic risk variants for ADHD: from Association to Biology

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