Noradrenaline release in the locus coeruleus modulates memory formation and consolidation; roles for alpha- and beta-adrenergic receptors

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Abstract

Noradrenaline, essential for the modulation of memory, is released in various parts of the brain from nerve terminals controlled by the locus coeruleus (LoC). Noradrenaline release consequent upon input from higher brain areas also occurs within the LoC itself. We examined the effect of noradrenaline on adrenergic receptors in the LoC on memory processing, using colored bead discrimination learning in the young domestic chick. We have shown previously that the release of noradrenaline in the hippocampus and cortex (mesopallium) is essential for acquisition and consolidation of short-term to intermediate and to long-term memory. Noradrenaline release within the LoC is triggered by the glutamatergic input from the forebrain. Inhibition by LoC injection of NMDA or AMPA receptor antagonists is rescued by injection of beta2-and beta3-adrenoceptor (AR) agonists in the hippocampus. We show that inhibition of alpha2A-ARs by BRL44408 in the LoC up to 30 min post-training consolidates weakly-reinforced learning. Conversely activation of alpha2A-ARs in the LoC at the times of consolidation between short-term, intermediate and long-term memory caused memory loss, which is likely to be due to a decreased release of noradrenaline within these time windows. The alpha2A-AR antagonist will block presynaptic inhibitory receptors leading to an increase in extracellular noradrenaline. This interpretation is supported by the actions of noradrenaline uptake blockers that produce the same memory outcome. BRL44408 in the mesopallium also caused memory enhancement. beta2-ARs are important in the first time window, whereas alpha1-, alpha2C-and beta3-ARs are important in the second time window. The results reveal that for successful memory formation noradrenaline release is necessary within the LoC as well as in other brain regions, at the time of consolidation of memory from short-term to intermediate and from intermediate to long-term memory.
Original languageEnglish
Pages (from-to)1209 - 1222
Number of pages14
JournalNeuroscience
Volume170
Issue number4
DOIs
Publication statusPublished - 2010

Cite this

@article{f376d2b17dcf40e986ee7dd90c8b0da1,
title = "Noradrenaline release in the locus coeruleus modulates memory formation and consolidation; roles for alpha- and beta-adrenergic receptors",
abstract = "Noradrenaline, essential for the modulation of memory, is released in various parts of the brain from nerve terminals controlled by the locus coeruleus (LoC). Noradrenaline release consequent upon input from higher brain areas also occurs within the LoC itself. We examined the effect of noradrenaline on adrenergic receptors in the LoC on memory processing, using colored bead discrimination learning in the young domestic chick. We have shown previously that the release of noradrenaline in the hippocampus and cortex (mesopallium) is essential for acquisition and consolidation of short-term to intermediate and to long-term memory. Noradrenaline release within the LoC is triggered by the glutamatergic input from the forebrain. Inhibition by LoC injection of NMDA or AMPA receptor antagonists is rescued by injection of beta2-and beta3-adrenoceptor (AR) agonists in the hippocampus. We show that inhibition of alpha2A-ARs by BRL44408 in the LoC up to 30 min post-training consolidates weakly-reinforced learning. Conversely activation of alpha2A-ARs in the LoC at the times of consolidation between short-term, intermediate and long-term memory caused memory loss, which is likely to be due to a decreased release of noradrenaline within these time windows. The alpha2A-AR antagonist will block presynaptic inhibitory receptors leading to an increase in extracellular noradrenaline. This interpretation is supported by the actions of noradrenaline uptake blockers that produce the same memory outcome. BRL44408 in the mesopallium also caused memory enhancement. beta2-ARs are important in the first time window, whereas alpha1-, alpha2C-and beta3-ARs are important in the second time window. The results reveal that for successful memory formation noradrenaline release is necessary within the LoC as well as in other brain regions, at the time of consolidation of memory from short-term to intermediate and from intermediate to long-term memory.",
author = "Gibbs, {Marie E} and Hutchinson, {Dana S} and Summers, {Roger J}",
year = "2010",
doi = "10.1016/j.neuroscience.2010.07.052",
language = "English",
volume = "170",
pages = "1209 -- 1222",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier",
number = "4",

}

Noradrenaline release in the locus coeruleus modulates memory formation and consolidation; roles for alpha- and beta-adrenergic receptors. / Gibbs, Marie E; Hutchinson, Dana S; Summers, Roger J.

In: Neuroscience, Vol. 170, No. 4, 2010, p. 1209 - 1222.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Noradrenaline release in the locus coeruleus modulates memory formation and consolidation; roles for alpha- and beta-adrenergic receptors

AU - Gibbs, Marie E

AU - Hutchinson, Dana S

AU - Summers, Roger J

PY - 2010

Y1 - 2010

N2 - Noradrenaline, essential for the modulation of memory, is released in various parts of the brain from nerve terminals controlled by the locus coeruleus (LoC). Noradrenaline release consequent upon input from higher brain areas also occurs within the LoC itself. We examined the effect of noradrenaline on adrenergic receptors in the LoC on memory processing, using colored bead discrimination learning in the young domestic chick. We have shown previously that the release of noradrenaline in the hippocampus and cortex (mesopallium) is essential for acquisition and consolidation of short-term to intermediate and to long-term memory. Noradrenaline release within the LoC is triggered by the glutamatergic input from the forebrain. Inhibition by LoC injection of NMDA or AMPA receptor antagonists is rescued by injection of beta2-and beta3-adrenoceptor (AR) agonists in the hippocampus. We show that inhibition of alpha2A-ARs by BRL44408 in the LoC up to 30 min post-training consolidates weakly-reinforced learning. Conversely activation of alpha2A-ARs in the LoC at the times of consolidation between short-term, intermediate and long-term memory caused memory loss, which is likely to be due to a decreased release of noradrenaline within these time windows. The alpha2A-AR antagonist will block presynaptic inhibitory receptors leading to an increase in extracellular noradrenaline. This interpretation is supported by the actions of noradrenaline uptake blockers that produce the same memory outcome. BRL44408 in the mesopallium also caused memory enhancement. beta2-ARs are important in the first time window, whereas alpha1-, alpha2C-and beta3-ARs are important in the second time window. The results reveal that for successful memory formation noradrenaline release is necessary within the LoC as well as in other brain regions, at the time of consolidation of memory from short-term to intermediate and from intermediate to long-term memory.

AB - Noradrenaline, essential for the modulation of memory, is released in various parts of the brain from nerve terminals controlled by the locus coeruleus (LoC). Noradrenaline release consequent upon input from higher brain areas also occurs within the LoC itself. We examined the effect of noradrenaline on adrenergic receptors in the LoC on memory processing, using colored bead discrimination learning in the young domestic chick. We have shown previously that the release of noradrenaline in the hippocampus and cortex (mesopallium) is essential for acquisition and consolidation of short-term to intermediate and to long-term memory. Noradrenaline release within the LoC is triggered by the glutamatergic input from the forebrain. Inhibition by LoC injection of NMDA or AMPA receptor antagonists is rescued by injection of beta2-and beta3-adrenoceptor (AR) agonists in the hippocampus. We show that inhibition of alpha2A-ARs by BRL44408 in the LoC up to 30 min post-training consolidates weakly-reinforced learning. Conversely activation of alpha2A-ARs in the LoC at the times of consolidation between short-term, intermediate and long-term memory caused memory loss, which is likely to be due to a decreased release of noradrenaline within these time windows. The alpha2A-AR antagonist will block presynaptic inhibitory receptors leading to an increase in extracellular noradrenaline. This interpretation is supported by the actions of noradrenaline uptake blockers that produce the same memory outcome. BRL44408 in the mesopallium also caused memory enhancement. beta2-ARs are important in the first time window, whereas alpha1-, alpha2C-and beta3-ARs are important in the second time window. The results reveal that for successful memory formation noradrenaline release is necessary within the LoC as well as in other brain regions, at the time of consolidation of memory from short-term to intermediate and from intermediate to long-term memory.

UR - http://www.sciencedirect.com/science/article/pii/S0306452210010559

U2 - 10.1016/j.neuroscience.2010.07.052

DO - 10.1016/j.neuroscience.2010.07.052

M3 - Article

VL - 170

SP - 1209

EP - 1222

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

IS - 4

ER -