Nonspherical Nanocapsules as Long-Circulating Drug Delivery Systems

Yunxin Xiao; Angel Tan; Alexander W. Jackson; Ben J. Boyd

doi:10.1021/acs.chemmater.1c03573

Nonspherical Nanocapsules as Long-Circulating Drug Delivery Systems

Yunxin Xiao, Angel Tan, Alexander W. Jackson, Ben J. Boyd

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Review Article › Research › peer-review

7 Citations (Scopus)

Abstract

Polymeric nanocapsules have been studied as drug delivery carriers for a great variety of drugs for more than 30 years. In particular, nonspherical polymeric nanoparticles with solid cores are highlighted for their capability to influence cellular uptake and circulation time in the bloodstream. However, the promising combination of nonspherical morphology and the existence of an internal cavity to encapsulate a high dose of pharmaceutical actives has not yet been fully achieved. This review systematically addresses the development of nonspherical nanocapsules with a cross-linked shell or self-assembled membrane (polymersomes). Ellipsoidal, tetrahedral, cubic, protrusion-shaped, dumbbell-shaped, and snowman-shaped nanocapsules are discussed. The relationship between the formed morphologies and the use of different templates, monomers, or methods of polymerization are elucidated for future design of more functional shapes.

Original language	English
Pages (from-to)	2503-2530
Number of pages	28
Journal	Chemistry of Materials
Volume	34
Issue number	6
DOIs	https://doi.org/10.1021/acs.chemmater.1c03573
Publication status	Published - 22 Mar 2021

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10.1021/acs.chemmater.1c03573

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title = "Nonspherical Nanocapsules as Long-Circulating Drug Delivery Systems",

abstract = "Polymeric nanocapsules have been studied as drug delivery carriers for a great variety of drugs for more than 30 years. In particular, nonspherical polymeric nanoparticles with solid cores are highlighted for their capability to influence cellular uptake and circulation time in the bloodstream. However, the promising combination of nonspherical morphology and the existence of an internal cavity to encapsulate a high dose of pharmaceutical actives has not yet been fully achieved. This review systematically addresses the development of nonspherical nanocapsules with a cross-linked shell or self-assembled membrane (polymersomes). Ellipsoidal, tetrahedral, cubic, protrusion-shaped, dumbbell-shaped, and snowman-shaped nanocapsules are discussed. The relationship between the formed morphologies and the use of different templates, monomers, or methods of polymerization are elucidated for future design of more functional shapes. ",

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AU - Xiao, Yunxin

AU - Tan, Angel

AU - Jackson, Alexander W.

AU - Boyd, Ben J.

N1 - Funding Information: The authors acknowledge the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology for support of this work and the salary of A.T. Publisher Copyright: © 2022 American Chemical Society.

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N2 - Polymeric nanocapsules have been studied as drug delivery carriers for a great variety of drugs for more than 30 years. In particular, nonspherical polymeric nanoparticles with solid cores are highlighted for their capability to influence cellular uptake and circulation time in the bloodstream. However, the promising combination of nonspherical morphology and the existence of an internal cavity to encapsulate a high dose of pharmaceutical actives has not yet been fully achieved. This review systematically addresses the development of nonspherical nanocapsules with a cross-linked shell or self-assembled membrane (polymersomes). Ellipsoidal, tetrahedral, cubic, protrusion-shaped, dumbbell-shaped, and snowman-shaped nanocapsules are discussed. The relationship between the formed morphologies and the use of different templates, monomers, or methods of polymerization are elucidated for future design of more functional shapes.

AB - Polymeric nanocapsules have been studied as drug delivery carriers for a great variety of drugs for more than 30 years. In particular, nonspherical polymeric nanoparticles with solid cores are highlighted for their capability to influence cellular uptake and circulation time in the bloodstream. However, the promising combination of nonspherical morphology and the existence of an internal cavity to encapsulate a high dose of pharmaceutical actives has not yet been fully achieved. This review systematically addresses the development of nonspherical nanocapsules with a cross-linked shell or self-assembled membrane (polymersomes). Ellipsoidal, tetrahedral, cubic, protrusion-shaped, dumbbell-shaped, and snowman-shaped nanocapsules are discussed. The relationship between the formed morphologies and the use of different templates, monomers, or methods of polymerization are elucidated for future design of more functional shapes.

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Nonspherical Nanocapsules as Long-Circulating Drug Delivery Systems

Abstract

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ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

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Nonspherical Nanocapsules as Long-Circulating Drug Delivery Systems

Abstract

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ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

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