Nonnucleoside reverse transcriptase inhibitors reduce HIV-1 production from latently infected resting CD4+ T cells following latency reversal

Jennifer M. Zerbato, Gilda Tachedjian, Nicolas Sluis-Cremer

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Therapeutic strategies that target the latent HIV-1 reservoir in resting CD4+ T cells of infected individuals are always administered in the presence of combination antiretroviral therapy. Using a primary cell of HIV-1 latency, we evaluated whether different antiviral drug classes affected latency reversal (as assessed by extracellular virus production) by anti-CD3/CD28 monoclonal antibodies or bryostatin1. We found that the nonnucleoside reverse transcriptase inhibitors efavirenz and rilpivirine significantly decreased HIV-1 production, by ≥1 log.

Original languageEnglish
Article numbere01736
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number3
DOIs
Publication statusPublished - 1 Mar 2017

Keywords

  • HIV-1
  • Latency
  • NNRTIs
  • Persistence
  • Reservoir

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