Noncytotoxic Roles of Granzymes in Health and Disease

Katlyn C. Richardson, Karen Jung, Julian Pardo, Christopher T. Turner, David J. Granville

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Granzymes are serine proteases previously believed to play exclusive and somewhat redundant roles in lymphocyte-mediated target cell death. However, recent studies have challenged this paradigm. Distinct substrate profiles and functions have since emerged for each granzyme while their dysregulated proteolytic activities have been linked to diverse pathologies.

Original languageEnglish
Pages (from-to)323-348
Number of pages26
JournalPhysiology
Volume37
Issue number6
DOIs
Publication statusPublished - Nov 2022

Keywords

  • barrier dysfunction
  • granzymes
  • inflammation
  • serine proteases
  • wound healing

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