@article{90b63b67d0754facb5f63f0a9ba37aca,
title = "Noncytotoxic Roles of Granzymes in Health and Disease",
abstract = "Granzymes are serine proteases previously believed to play exclusive and somewhat redundant roles in lymphocyte-mediated target cell death. However, recent studies have challenged this paradigm. Distinct substrate profiles and functions have since emerged for each granzyme while their dysregulated proteolytic activities have been linked to diverse pathologies.",
keywords = "barrier dysfunction, granzymes, inflammation, serine proteases, wound healing",
author = "Richardson, {Katlyn C.} and Karen Jung and Julian Pardo and Turner, {Christopher T.} and Granville, {David J.}",
note = "Funding Information: This study was funded by the Canadian Institutes of Health Research, Michael Smith Foundation for Health Research, Cancer Research Society, Eczema Society of Canada, LEO Foundation, Mitacs Canada, Rick Hansen Institute (to D.J.G.), and Canadian Institutes of Health Research (to K.C.R). Publisher Copyright: {\textcopyright} 2022 Int. Union Physiol. Sci./Am. Physiol. Soc.",
year = "2022",
month = nov,
doi = "10.1152/physiol.00011.2022",
language = "English",
volume = "37",
pages = "323--348",
journal = "Physiology",
issn = "1548-9213",
publisher = "American Physiological Society",
number = "6",
}