Non-traditional systemic treatments for diabetic retinopathy: An evidence-based review

Rafael Simó, Stefania Ballarini, José Cunha-Vaz, Linong Ji, Hermann Haller, Paul Zimmet, Tien Y. Wong

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)


The rapid escalation in the global prevalence diabetes, with more than 30% being afflicted with diabetic retinopathy (DR), means it is likely that associated vision-threatening conditions will also rise substantially. This means that new therapeutic approaches need to be found that go beyond the current standards of diabetic care, and which are effective in the early stages of the disease. In recent decades several new pharmacological agents have been investigated for their effectiveness in preventing the appearance and progression of DR or in reversing DR; some with limited success while others appear promising. This up-to-date critical review of non-traditional systemic treatments for DR is based on the published evidence in MEDLINE spanning 1980-December 2014. It discusses a number of therapeutic options, paying particular attention to the mechanisms of action and the clinical evidence for the use of renin-angiotensin system blockade, fenofibrate and calcium dobesilate monohydrate in DR.

Original languageEnglish
Pages (from-to)2580-2589
Number of pages10
JournalCurrent Medicinal Chemistry
Issue number21
Publication statusPublished - Jan 2015
Externally publishedYes


  • Calcium dobesilate
  • Diabetic retinopathy
  • Fenofibrate
  • Renin-angiotensin system blockade

Cite this