TY - JOUR
T1 - Non-toxigenic Clostridium sordellii: Clinical and microbiological features of a case of cholangitis-associated bacteremia
AU - Walk, Seth
AU - Jain, Ruchika
AU - Trivedi, Itishree
AU - Grossman, Sylvia
AU - Newton, Duane
AU - Thelen, Tennille
AU - Hao, Yibai
AU - Songer, J Glenn
AU - Carter, Glen
AU - Lyras, Dena
AU - Young, Vincent
AU - Aronoff, David
PY - 2011
Y1 - 2011
N2 - Toxigenic Clostridium sordellii strains are increasingly recognized to cause highly lethal infections in humans that are typified by a toxic shock syndrome (TSS). Two glucosylating toxins, lethal toxin (TcsL) and hemorrhagic toxin (TcsH) are believed to be important in the pathogenesis of TSS. While non-toxigenic strains of C. sordellii demonstrate reduced cytotoxicity in vitro and lower virulence in animal models of infection, there are few data regarding their behavior in humans. Here we report a non-TSS C. sordellii infection in the context of a polymicrobial bacterial cholangitis. The C. sordellii strain associated with this infection did not carry either the TcsL-encoding tcsL gene or the tcsH gene for TcsH. In addition, the strain was neither cytotoxic in vitro nor lethal in a murine sepsis model. These results provide additional correlative evidence that TcsL and TcsH increase the risk of mortality during C. sordellii infections.
AB - Toxigenic Clostridium sordellii strains are increasingly recognized to cause highly lethal infections in humans that are typified by a toxic shock syndrome (TSS). Two glucosylating toxins, lethal toxin (TcsL) and hemorrhagic toxin (TcsH) are believed to be important in the pathogenesis of TSS. While non-toxigenic strains of C. sordellii demonstrate reduced cytotoxicity in vitro and lower virulence in animal models of infection, there are few data regarding their behavior in humans. Here we report a non-TSS C. sordellii infection in the context of a polymicrobial bacterial cholangitis. The C. sordellii strain associated with this infection did not carry either the TcsL-encoding tcsL gene or the tcsH gene for TcsH. In addition, the strain was neither cytotoxic in vitro nor lethal in a murine sepsis model. These results provide additional correlative evidence that TcsL and TcsH increase the risk of mortality during C. sordellii infections.
UR - http://www.ncbi.nlm.nih.gov/pubmed/21726656
UR - https://www.scopus.com/pages/publications/80053105866
U2 - 10.1016/j.anaerobe.2011.06.009
DO - 10.1016/j.anaerobe.2011.06.009
M3 - Article
SN - 1075-9964
VL - 17
SP - 252
EP - 256
JO - Anaerobe
JF - Anaerobe
IS - 5
ER -