Non-toxigenic Clostridium sordellii: Clinical and microbiological features of a case of cholangitis-associated bacteremia

Seth Walk, Ruchika Jain, Itishree Trivedi, Sylvia Grossman, Duane Newton, Tennille Thelen, Yibai Hao, J Glenn Songer, Glen Carter, Dena Lyras, Vincent Young, David Aronoff

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Toxigenic Clostridium sordellii strains are increasingly recognized to cause highly lethal infections in humans that are typified by a toxic shock syndrome (TSS). Two glucosylating toxins, lethal toxin (TcsL) and hemorrhagic toxin (TcsH) are believed to be important in the pathogenesis of TSS. While non-toxigenic strains of C. sordellii demonstrate reduced cytotoxicity in vitro and lower virulence in animal models of infection, there are few data regarding their behavior in humans. Here we report a non-TSS C. sordellii infection in the context of a polymicrobial bacterial cholangitis. The C. sordellii strain associated with this infection did not carry either the TcsL-encoding tcsL gene or the tcsH gene for TcsH. In addition, the strain was neither cytotoxic in vitro nor lethal in a murine sepsis model. These results provide additional correlative evidence that TcsL and TcsH increase the risk of mortality during C. sordellii infections.
Original languageEnglish
Pages (from-to)252 - 256
Number of pages5
JournalAnaerobe
Volume17
Issue number5
DOIs
Publication statusPublished - 2011

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