Non-fouling microfluidic chip produced by radio frequency tetraglyme plasma deposition

Malinda Salim, Gautam Mishra, Gregory J.S. Fowler, Brian O'Sullivan, Phillip C. Wright, Sally L. McArthur

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)


This Technical Note presents the direct surface modification of a glass/PTFE hybrid microfluidic chip, via radio frequency glow discharge plasma polymerisation of tetraethlylene glycol dimethylether (tetraglyme), to produce hydrophilic, non-fouling, PEO-like surfaces. We use several techniques including X-ray photoelectron spectroscopy (XPS), direct enzyme-linked immunosorbent assays (ELISA) and immunofluorescent imaging to investigate the channel coatings. Our results indicate the successful deposition of a PEO-like coating onto microchannel surfaces that has both solution and shelf stability (>3 months) and is capable of preventing fibrinogen adsorption to the microchannel surfaces.

Original languageEnglish
Pages (from-to)523-525
Number of pages3
JournalLab on a Chip
Issue number4
Publication statusPublished - 1 Jan 2007
Externally publishedYes

Cite this