Non-Coding RNAs in Mammalian Sexual Development

Lindsey McFarlane, Dagmar Wilhelm

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

The present decade is witnessing a paradigm shift in our understanding of gene regulation. RNA, once relegated to an intermediary between DNA and protein, has emerged as a key contributor in the coordination of complex developmental pathways. For sexually reproducing organisms, propagation of the species is accomplished via an elaborate sexual phenotype. In mammals this consists of a highly complex cell lineage that has the capacity for intricate self-differentiation whilst maintaining the potential to generate all cell types upon fertilization. In addition, mammals possess a diverse range of somatic reproductive tissues and organs that often undergo dynamic morphological changes in response to a variety of external and internal cues. Although the protein component required to mediate these processes continues to be vigorously investigated, it is becoming increasingly apparent that an understanding of the non-coding RNA (ncRNA) component is required to develop a comprehensive picture of mammalian sexual development.
Original languageEnglish
Pages (from-to)302 - 316
Number of pages15
JournalSexual Development
Volume3
Issue number6
DOIs
Publication statusPublished - 2009
Externally publishedYes

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