TY - CHAP
T1 - Non-coding RNAs: An Introduction
AU - Yang, Jennifer X
AU - Rastetter, Raphael H
AU - Wilhelm, Dagmar
PY - 2016
Y1 - 2016
N2 - For many years the main role of RNA, it addition to the housekeeping functions of for example tRNAs and rRNAs, was believed to be a messenger between the genes encoded on the DNA and the functional units of the cell, the proteins. This changed drastically with the identification of the first small non-coding RNA, termed microRNA, some 20 years ago. This discovery opened the field of regulatory RNAs with no or little protein-coding potential. Since then many new classes of regulatory non-coding RNAs, including endogenous small interfering RNAs (endo-siRNAs), PIWI-associated RNAs (piRNAs), and long non-coding RNAs, have been identified and we have made amazing progress in elucidating their expression, biogenesis, mechanisms and mode of action, and function in many, if not all, biological processes. In this chapter we provide an introduction about the current knowledge of the main classes of non-coding RNAs, what is know about their biogenesis and mechanism of function.
AB - For many years the main role of RNA, it addition to the housekeeping functions of for example tRNAs and rRNAs, was believed to be a messenger between the genes encoded on the DNA and the functional units of the cell, the proteins. This changed drastically with the identification of the first small non-coding RNA, termed microRNA, some 20 years ago. This discovery opened the field of regulatory RNAs with no or little protein-coding potential. Since then many new classes of regulatory non-coding RNAs, including endogenous small interfering RNAs (endo-siRNAs), PIWI-associated RNAs (piRNAs), and long non-coding RNAs, have been identified and we have made amazing progress in elucidating their expression, biogenesis, mechanisms and mode of action, and function in many, if not all, biological processes. In this chapter we provide an introduction about the current knowledge of the main classes of non-coding RNAs, what is know about their biogenesis and mechanism of function.
UR - http://www.ncbi.nlm.nih.gov/pubmed/26659485
U2 - 10.1007/978-94-017-7417-8_2
DO - 10.1007/978-94-017-7417-8_2
M3 - Chapter (Book)
SN - 978-94-017-7415-4
T3 - Advances in Experimental Medicine and Biology
SP - 13
EP - 32
BT - Non-coding RNA and the Reproductive System
A2 - Wilhelm, Dagmar
A2 - Bernard, Pascal
PB - Springer
CY - The Netherlands
ER -