Non-canonical IKKs side with N4BP1 against the family

Research output: Contribution to journalComment / DebateOtherpeer-review

Abstract

The ubiquitin-binding endoribonuclease N4BP1 is a critical immunosuppressor, but the mechanism by which it acts to constrain TLR-induced inflammatory cytokine production has remained unclear. In this issue of Immunity, Gitlin et al. find that N4BP1 works in concert with the non-canonical IκB kinase (IKK) to limit activity of the IKK complex.

Original languageEnglish
Pages (from-to)929-932
Number of pages4
JournalImmunity
Volume57
Issue number5
DOIs
Publication statusPublished - 14 May 2024

Cite this