Non-bronchiolitis obliterans syndrome forms of chronic lung allograft dysfunction

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Abstract

The bronchiolitis obliterans syndrome (BOS) has been described as the clinical correlate of chronic lung allograft rejection and defi ned as irreversible airfl ow obstruction in the absence of other causes. However, it has become apparent that BOS does not explain all chronic lung allograft dysfunction (CLAD) and that a variety of other etiologies with a mixed obstructive and restrictive pattern on spirometry, or even a pure restrictive picture (restrictive allograft syndrome, or RAS), are also identifi able. Surgical, mechanical, vascular obstructive, infectious, and infi ltrative processes, as well as a whole range of chronic lung allograft rejection entities need to be considered in making a diagnosis of CLAD. The performance of any lung allograft is really the sum-of-the-parts of all of these processes, and considering non-BOS CLAD in all its forms may potentially provide more therapeutic options than just considering BOS alone as the explanation for declining lung function.

Original languageEnglish
Title of host publicationBronchiolitis Obliterans Syndrome in Lung Transplantation
EditorsKeith C. Meyer, Allan R. Glanville
Place of PublicationNew York NY USA
PublisherHumana Press
Pages47-58
Number of pages12
ISBN (Electronic)9781461476368
ISBN (Print)9781461476351
DOIs
Publication statusPublished - 1 Jan 2013

Keywords

  • Allograft rejection
  • Bronchiolitis obliterans syndrome
  • Chronic lung allograft dysfunction
  • Chronic rejection
  • Lung transplantation
  • Obliterative bronchiolitis
  • Restrictive lung allograft syndrome

Cite this

Snell, G. I., Levvey, B. J., & Westall, G. P. (2013). Non-bronchiolitis obliterans syndrome forms of chronic lung allograft dysfunction. In K. C. Meyer, & A. R. Glanville (Eds.), Bronchiolitis Obliterans Syndrome in Lung Transplantation (pp. 47-58). New York NY USA: Humana Press. https://doi.org/10.1007/978-1-4614-7636-8_3
Snell, Gregory I. ; Levvey, Bronwyn J. ; Westall, Glen P. / Non-bronchiolitis obliterans syndrome forms of chronic lung allograft dysfunction. Bronchiolitis Obliterans Syndrome in Lung Transplantation. editor / Keith C. Meyer ; Allan R. Glanville. New York NY USA : Humana Press, 2013. pp. 47-58
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Snell, GI, Levvey, BJ & Westall, GP 2013, Non-bronchiolitis obliterans syndrome forms of chronic lung allograft dysfunction. in KC Meyer & AR Glanville (eds), Bronchiolitis Obliterans Syndrome in Lung Transplantation. Humana Press, New York NY USA, pp. 47-58. https://doi.org/10.1007/978-1-4614-7636-8_3

Non-bronchiolitis obliterans syndrome forms of chronic lung allograft dysfunction. / Snell, Gregory I.; Levvey, Bronwyn J.; Westall, Glen P.

Bronchiolitis Obliterans Syndrome in Lung Transplantation. ed. / Keith C. Meyer; Allan R. Glanville. New York NY USA : Humana Press, 2013. p. 47-58.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

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Snell GI, Levvey BJ, Westall GP. Non-bronchiolitis obliterans syndrome forms of chronic lung allograft dysfunction. In Meyer KC, Glanville AR, editors, Bronchiolitis Obliterans Syndrome in Lung Transplantation. New York NY USA: Humana Press. 2013. p. 47-58 https://doi.org/10.1007/978-1-4614-7636-8_3