Non-benzimidazole containing inhibitors of respiratory syncytial virus

David C Pryde, Thien Duc Tran, Iain Gardner, Helen Bright, Paul Stupple, Sebastien Galan, Liam Alsop, Lesa Watson, Donald S. Middleton, Satish Dayal, Michelle Platts, Edward J. Murray, Tanya Parkinson, Robert Webster

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9 Citations (Scopus)

Abstract

Several non-benzimidazole containing inhibitors of respiratory syncytial virus are described. Core template modification, analysis of antiviral activity, physicochemistry and optimisation of properties led to the thiazole-imidazole 13, that showed a good potency and pharmacokinetic profile in the rat.

Original languageEnglish
Pages (from-to)827-833
Number of pages7
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number3
DOIs
Publication statusPublished - 1 Feb 2013
Externally publishedYes

Keywords

  • Antiviral
  • Benzimidazole
  • Heterocycle
  • RSV
  • Virus

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