Non-absorptive clearance from airways

Martin Donnelley; Mark Gardner; Kaye Morgan; David Parsons

doi:10.1016/B978-0-12-814974-4.00002-X

Non-absorptive clearance from airways

Martin Donnelley, Mark Gardner, Kaye Morgan, David Parsons

School of Physics and Astronomy

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

7 Citations (Scopus)

Abstract

The lung is protected by multiple mechanisms, but the primary defense is mucociliary clearance (MCC). MCC is responsible for removing noxious particulates that may reduce lung health, but it can also clear inhaled pharmaceuticals. Effective MCC relies on the correct ciliary structure and pattern of movement, combined with mucus rheology characteristics, that together facilitate particle capture and transport. Abnormalities in these result in muco-obstructive disease.

Original language	English
Title of host publication	Inhaled Medicines
Subtitle of host publication	Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches
Editors	Stavros Kassinos, Per Backman, Joy Conway, Anthony J. Hickey
Place of Publication	London, United Kingdom
Publisher	Elsevier
Chapter	8
Pages	197-223
Number of pages	27
ISBN (Electronic)	9780128149744
DOIs	https://doi.org/10.1016/B978-0-12-814974-4.00002-X
Publication status	Published - 2021

Keywords

Airways
Computed tomography
Muco-obstructive disease
Mucociliary clearance
Non-absorptive clearance
Optical coherence tomography
Respiratory system
Synchrotron
X-ray

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10.1016/B978-0-12-814974-4.00002-X

Cite this

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title = "Non-absorptive clearance from airways",

abstract = "The lung is protected by multiple mechanisms, but the primary defense is mucociliary clearance (MCC). MCC is responsible for removing noxious particulates that may reduce lung health, but it can also clear inhaled pharmaceuticals. Effective MCC relies on the correct ciliary structure and pattern of movement, combined with mucus rheology characteristics, that together facilitate particle capture and transport. Abnormalities in these result in muco-obstructive disease.",

keywords = "Airways, Computed tomography, Muco-obstructive disease, Mucociliary clearance, Non-absorptive clearance, Optical coherence tomography, Respiratory system, Synchrotron, X-ray",

author = "Martin Donnelley and Mark Gardner and Kaye Morgan and David Parsons",

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doi = "10.1016/B978-0-12-814974-4.00002-X",

language = "English",

pages = "197--223",

editor = "Stavros Kassinos and Per Backman and Joy Conway and Hickey, \{Anthony J.\}",

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Non-absorptive clearance from airways. / Donnelley, Martin; Gardner, Mark; Morgan, Kaye et al.
Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches. ed. / Stavros Kassinos; Per Backman; Joy Conway; Anthony J. Hickey. London, United Kingdom: Elsevier, 2021. p. 197-223.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

TY - CHAP

T1 - Non-absorptive clearance from airways

AU - Donnelley, Martin

AU - Gardner, Mark

AU - Morgan, Kaye

AU - Parsons, David

PY - 2021

Y1 - 2021

N2 - The lung is protected by multiple mechanisms, but the primary defense is mucociliary clearance (MCC). MCC is responsible for removing noxious particulates that may reduce lung health, but it can also clear inhaled pharmaceuticals. Effective MCC relies on the correct ciliary structure and pattern of movement, combined with mucus rheology characteristics, that together facilitate particle capture and transport. Abnormalities in these result in muco-obstructive disease.

AB - The lung is protected by multiple mechanisms, but the primary defense is mucociliary clearance (MCC). MCC is responsible for removing noxious particulates that may reduce lung health, but it can also clear inhaled pharmaceuticals. Effective MCC relies on the correct ciliary structure and pattern of movement, combined with mucus rheology characteristics, that together facilitate particle capture and transport. Abnormalities in these result in muco-obstructive disease.

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KW - Computed tomography

KW - Muco-obstructive disease

KW - Mucociliary clearance

KW - Non-absorptive clearance

KW - Optical coherence tomography

KW - Respiratory system

KW - Synchrotron

KW - X-ray

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DO - 10.1016/B978-0-12-814974-4.00002-X

M3 - Chapter (Book)

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EP - 223

BT - Inhaled Medicines

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A2 - Conway, Joy

A2 - Hickey, Anthony J.

PB - Elsevier

CY - London, United Kingdom

ER -

Non-absorptive clearance from airways

Abstract

Keywords

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