Nod1 and Nod2 and the immune response to bacteria

Maria Liaskos, Dana Philpott

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other


The mammalian host has evolved to develop a diverse array of innate immune receptors and strategies to defend itself against infection by microbial pathogens. These germ-line-encoded and conserved microbial receptors, called pattern recognition receptors (PRRs), are associated with the membranes or within the cytosol of host cells. PRRs enable the host to rapidly respond to pathogen-associated molecular patterns (PAMPs), as a first line of defence against microbial intrusion.
Original languageEnglish
Title of host publicationMolecular Genetics of Inflammatory Bowel Disease
EditorsMario D'Amato, John D Rioux
Place of PublicationNew York, United States
Pages191 - 217
Number of pages27
ISBN (Print)9781461482550
Publication statusPublished - 2013

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