Nocturnal autonomic function in preschool children with sleep-disordered breathing

Lauren Nisbet; Stephanie Yiallourou; Gillian Michelle Nixon; Sarah Nichole Biggs; Margot J Davey; John A Trinder; Lisa Mary Walter; Rosemary Sylvia Claire Horne

doi:10.1016/j.sleep.2013.07.010

Nocturnal autonomic function in preschool children with sleep-disordered breathing

Lauren Nisbet, Stephanie Yiallourou, Gillian Michelle Nixon, Sarah Nichole Biggs, Margot J Davey, John A Trinder, Lisa Mary Walter, Rosemary Sylvia Claire Horne

Hudson Institute - The Ritchie Centre

Research output: Contribution to journal › Article › Research › peer-review

51 Citations (Scopus)

Abstract

Obstructive sleep apnea (OSA) is associated with autonomic dysfunction in adults and school-aged children; however, this association has not been investigated in preschool children. We aimed to analyze heart rate variability (HRV) and catecholamine levels in preschool children with OSA. METHODS: One hundred and forty-two snoring children aged 3-5years and 38 nonsnoring control group children underwent overnight polysomnography (PSG). Nocturnal urinary catecholamines were measured in 120 children. Children were grouped according to their obstructive apnea-hypopnea index (OAHI) (control [no snoring], OAHI1event/h; primary snoring, OAHI1event/h; mild OSA OAHI>15events/h; moderate to severe [MS] OSA, OAHI>5events/h). The HRV parameters for each child were averaged during rapid eye movement (REM) and non-REM (NREM) sleep. RESULTS: During stable sleep, low-frequency (LF) HRV was similar between groups. High-frequency (HF) HRV was higher in the MS OSA group compared with the control group during all sleep stages (NREM sleep stages 1 and 2 [NREM1/2], 4234+/-523ms2 vs 2604+/-457ms2; NREM sleep stages 3 and 4 [NREM3/4], 4152+/-741ms2 vs 3035+/-647ms2; REM, 1836+/-255ms2 vs 1456+/-292ms2; P

Original language	English
Pages (from-to)	1310 - 1316
Number of pages	7
Journal	Sleep Medicine
Volume	14
Issue number	12
DOIs	https://doi.org/10.1016/j.sleep.2013.07.010
Publication status	Published - 2013

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10.1016/j.sleep.2013.07.010

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@article{79202b5d08304abf9cf1245f701d83bb,

title = "Nocturnal autonomic function in preschool children with sleep-disordered breathing",

abstract = "Obstructive sleep apnea (OSA) is associated with autonomic dysfunction in adults and school-aged children; however, this association has not been investigated in preschool children. We aimed to analyze heart rate variability (HRV) and catecholamine levels in preschool children with OSA. METHODS: One hundred and forty-two snoring children aged 3-5years and 38 nonsnoring control group children underwent overnight polysomnography (PSG). Nocturnal urinary catecholamines were measured in 120 children. Children were grouped according to their obstructive apnea-hypopnea index (OAHI) (control [no snoring], OAHI1event/h; primary snoring, OAHI1event/h; mild OSA OAHI>15events/h; moderate to severe [MS] OSA, OAHI>5events/h). The HRV parameters for each child were averaged during rapid eye movement (REM) and non-REM (NREM) sleep. RESULTS: During stable sleep, low-frequency (LF) HRV was similar between groups. High-frequency (HF) HRV was higher in the MS OSA group compared with the control group during all sleep stages (NREM sleep stages 1 and 2 [NREM1/2], 4234+/-523ms2 vs 2604+/-457ms2; NREM sleep stages 3 and 4 [NREM3/4], 4152+/-741ms2 vs 3035+/-647ms2; REM, 1836+/-255ms2 vs 1456+/-292ms2; P",

author = "Lauren Nisbet and Stephanie Yiallourou and Nixon, {Gillian Michelle} and Biggs, {Sarah Nichole} and Davey, {Margot J} and Trinder, {John A} and Walter, {Lisa Mary} and Horne, {Rosemary Sylvia Claire}",

year = "2013",

doi = "10.1016/j.sleep.2013.07.010",

language = "English",

volume = "14",

pages = "1310 -- 1316",

journal = "Sleep Medicine",

issn = "1389-9457",

publisher = "Elsevier BV",

number = "12",

}

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T1 - Nocturnal autonomic function in preschool children with sleep-disordered breathing

AU - Nisbet, Lauren

AU - Yiallourou, Stephanie

AU - Nixon, Gillian Michelle

AU - Biggs, Sarah Nichole

AU - Davey, Margot J

AU - Trinder, John A

AU - Walter, Lisa Mary

AU - Horne, Rosemary Sylvia Claire

PY - 2013

Y1 - 2013

N2 - Obstructive sleep apnea (OSA) is associated with autonomic dysfunction in adults and school-aged children; however, this association has not been investigated in preschool children. We aimed to analyze heart rate variability (HRV) and catecholamine levels in preschool children with OSA. METHODS: One hundred and forty-two snoring children aged 3-5years and 38 nonsnoring control group children underwent overnight polysomnography (PSG). Nocturnal urinary catecholamines were measured in 120 children. Children were grouped according to their obstructive apnea-hypopnea index (OAHI) (control [no snoring], OAHI1event/h; primary snoring, OAHI1event/h; mild OSA OAHI>15events/h; moderate to severe [MS] OSA, OAHI>5events/h). The HRV parameters for each child were averaged during rapid eye movement (REM) and non-REM (NREM) sleep. RESULTS: During stable sleep, low-frequency (LF) HRV was similar between groups. High-frequency (HF) HRV was higher in the MS OSA group compared with the control group during all sleep stages (NREM sleep stages 1 and 2 [NREM1/2], 4234+/-523ms2 vs 2604+/-457ms2; NREM sleep stages 3 and 4 [NREM3/4], 4152+/-741ms2 vs 3035+/-647ms2; REM, 1836+/-255ms2 vs 1456+/-292ms2; P

AB - Obstructive sleep apnea (OSA) is associated with autonomic dysfunction in adults and school-aged children; however, this association has not been investigated in preschool children. We aimed to analyze heart rate variability (HRV) and catecholamine levels in preschool children with OSA. METHODS: One hundred and forty-two snoring children aged 3-5years and 38 nonsnoring control group children underwent overnight polysomnography (PSG). Nocturnal urinary catecholamines were measured in 120 children. Children were grouped according to their obstructive apnea-hypopnea index (OAHI) (control [no snoring], OAHI1event/h; primary snoring, OAHI1event/h; mild OSA OAHI>15events/h; moderate to severe [MS] OSA, OAHI>5events/h). The HRV parameters for each child were averaged during rapid eye movement (REM) and non-REM (NREM) sleep. RESULTS: During stable sleep, low-frequency (LF) HRV was similar between groups. High-frequency (HF) HRV was higher in the MS OSA group compared with the control group during all sleep stages (NREM sleep stages 1 and 2 [NREM1/2], 4234+/-523ms2 vs 2604+/-457ms2; NREM sleep stages 3 and 4 [NREM3/4], 4152+/-741ms2 vs 3035+/-647ms2; REM, 1836+/-255ms2 vs 1456+/-292ms2; P

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U2 - 10.1016/j.sleep.2013.07.010

DO - 10.1016/j.sleep.2013.07.010

M3 - Article

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VL - 14

SP - 1310

EP - 1316

JO - Sleep Medicine

JF - Sleep Medicine

IS - 12

ER -

Nocturnal autonomic function in preschool children with sleep-disordered breathing

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Impact of sleep disordered breathing on cardiovascular, behavioural and neurocognitive function in preschool children

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Nocturnal autonomic function in preschool children with sleep-disordered breathing

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Impact of sleep disordered breathing on cardiovascular, behavioural and neurocognitive function in preschool children

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