Abstract
Persistent infections with cytomegalovirus (CMV) differentially affect the host immune phenotype in middle-aged males and females. Because CMV already impacts on T-cell memory at a young age, we studied whether these effects were modified by sex in 1,079 children with an average age of 6 years. Sex and CMV independently impacted on multiple B-cell and T-cell subsets. However, there was no significant effect of their interaction. Importantly, the effects of sex and CMV were in part explained by age and infection with other herpesviruses. Thus, immune aging is likely to be more complex, with involvement of hormonal changes with age, socioeconomic status, birth characteristics, and pathogen exposure.
| Original language | English |
|---|---|
| Pages (from-to) | 883-888 |
| Number of pages | 6 |
| Journal | Journal of Infectious Diseases |
| Volume | 215 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 15 Mar 2017 |
Keywords
- Age
- Children
- Cytomegalovirus
- Sex
- T cells
Cite this
}
No interactive effects of sex and persistent cytomegalovirus on immune phenotypes in young children : The generation R study. / Jansen, Michelle A E; Van Den Heuvel, Diana; Jaddoe, Vincent W V; Moll, Henriette A.; Van Zelm, Menno C.
In: Journal of Infectious Diseases, Vol. 215, No. 6, 15.03.2017, p. 883-888.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - No interactive effects of sex and persistent cytomegalovirus on immune phenotypes in young children
T2 - The generation R study
AU - Jansen, Michelle A E
AU - Van Den Heuvel, Diana
AU - Jaddoe, Vincent W V
AU - Moll, Henriette A.
AU - Van Zelm, Menno C.
PY - 2017/3/15
Y1 - 2017/3/15
N2 - Persistent infections with cytomegalovirus (CMV) differentially affect the host immune phenotype in middle-aged males and females. Because CMV already impacts on T-cell memory at a young age, we studied whether these effects were modified by sex in 1,079 children with an average age of 6 years. Sex and CMV independently impacted on multiple B-cell and T-cell subsets. However, there was no significant effect of their interaction. Importantly, the effects of sex and CMV were in part explained by age and infection with other herpesviruses. Thus, immune aging is likely to be more complex, with involvement of hormonal changes with age, socioeconomic status, birth characteristics, and pathogen exposure.
AB - Persistent infections with cytomegalovirus (CMV) differentially affect the host immune phenotype in middle-aged males and females. Because CMV already impacts on T-cell memory at a young age, we studied whether these effects were modified by sex in 1,079 children with an average age of 6 years. Sex and CMV independently impacted on multiple B-cell and T-cell subsets. However, there was no significant effect of their interaction. Importantly, the effects of sex and CMV were in part explained by age and infection with other herpesviruses. Thus, immune aging is likely to be more complex, with involvement of hormonal changes with age, socioeconomic status, birth characteristics, and pathogen exposure.
KW - Age
KW - Children
KW - Cytomegalovirus
KW - Sex
KW - T cells
UR - http://www.scopus.com/inward/record.url?scp=85019667874&partnerID=8YFLogxK
U2 - 10.1093/infdis/jix064
DO - 10.1093/infdis/jix064
M3 - Article
VL - 215
SP - 883
EP - 888
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 6
ER -