Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 431 - 440 |
| Number of pages | 10 |
| Journal | Psychiatry Research |
| Volume | 228 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2015 |
Cite this
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No evidence for mirror system dysfunction in schizophrenia from a multimodal TMS/EEG study. / Andrews, Sophie Claire; Enticott, Peter Gregory; Hoy, Kate Elizabeth; Thomson, Richard Hilton Siddall; Fitzgerald, Paul Bernard.
In: Psychiatry Research, Vol. 228, No. 3, 2015, p. 431 - 440.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - No evidence for mirror system dysfunction in schizophrenia from a multimodal TMS/EEG study
AU - Andrews, Sophie Claire
AU - Enticott, Peter Gregory
AU - Hoy, Kate Elizabeth
AU - Thomson, Richard Hilton Siddall
AU - Fitzgerald, Paul Bernard
PY - 2015
Y1 - 2015
N2 - Dysfunctional mirror neuron systems have been proposed to contribute to the social cognitive deficits observed in schizophrenia. A few studies have explored mirror systems in schizophrenia using various techniques such as TMS (levels of motor resonance) or EEG (levels of mu suppression), with mixed results. This study aimed to use a novel multimodal approach (i.e. concurrent TMS and EEG) to further investigate mirror systems and social cognition in schizophrenia. Nineteen individuals with schizophrenia or schizoaffective disorder and 19 healthy controls participated. Single-pulse TMS was applied to M1 during the observation of hand movements designed to elicit mirror system activity. Single EEG electrodes (C3, CZ, C4) recorded brain activity. Participants also completed facial affect recognition and theory of mind tasks. The schizophrenia group showed significant deficits in facial affect recognition and higher level theory of mind compared to healthy controls. A significant positive relationship was revealed between mu suppression and motor resonance for the overall sample, indicating concurrent validity of these measures. Levels of mu suppression and motor resonance were not significantly different between groups. These findings indicate that in stable outpatients with schizophrenia, mirror system functioning is intact, and therefore their social cognitive difficulties may be caused by alternative pathophysiology
AB - Dysfunctional mirror neuron systems have been proposed to contribute to the social cognitive deficits observed in schizophrenia. A few studies have explored mirror systems in schizophrenia using various techniques such as TMS (levels of motor resonance) or EEG (levels of mu suppression), with mixed results. This study aimed to use a novel multimodal approach (i.e. concurrent TMS and EEG) to further investigate mirror systems and social cognition in schizophrenia. Nineteen individuals with schizophrenia or schizoaffective disorder and 19 healthy controls participated. Single-pulse TMS was applied to M1 during the observation of hand movements designed to elicit mirror system activity. Single EEG electrodes (C3, CZ, C4) recorded brain activity. Participants also completed facial affect recognition and theory of mind tasks. The schizophrenia group showed significant deficits in facial affect recognition and higher level theory of mind compared to healthy controls. A significant positive relationship was revealed between mu suppression and motor resonance for the overall sample, indicating concurrent validity of these measures. Levels of mu suppression and motor resonance were not significantly different between groups. These findings indicate that in stable outpatients with schizophrenia, mirror system functioning is intact, and therefore their social cognitive difficulties may be caused by alternative pathophysiology
UR - http://www.sciencedirect.com/science/article/pii/S0165178115003728
U2 - 10.1016/j.psychres.2015.05.067
DO - 10.1016/j.psychres.2015.05.067
M3 - Article
VL - 228
SP - 431
EP - 440
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 3
ER -