No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swine

Maciej F. Boni; Gavin J. D. Smith; Edward C. Holmes; Dhanasekaran Vijaykrishna

doi:10.1016/j.gene.2011.10.041

No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swine

Maciej F. Boni, Gavin J. D. Smith, Edward C. Holmes, Dhanasekaran Vijaykrishna

Research output: Contribution to journal › Letter › Other › peer-review

14 Citations (Scopus)

Abstract

Hao (2011) reported that the PB2 genes of three swine influenza A viruses were likely generated through homologous recombination between two closely related parental strains. However, we show that Hao's observation is an artifact of incorrect taxon sampling arising through the lack of an appropriate evolutionary context. Through rigorous phylogenetic analyses we explain the evolutionary origins of these stains and confirm the lack of any statistical support for intra-segmental recombination.

Original language	English
Pages (from-to)	242-245
Number of pages	4
Journal	Gene
Volume	494
Issue number	2
DOIs	https://doi.org/10.1016/j.gene.2011.10.041
Publication status	Published - 25 Feb 2012
Externally published	Yes

Keywords

Genome
Influenza A virus
Pandemic influenza
Swine influenza

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10.1016/j.gene.2011.10.041

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title = "No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swine",

abstract = "Hao (2011) reported that the PB2 genes of three swine influenza A viruses were likely generated through homologous recombination between two closely related parental strains. However, we show that Hao's observation is an artifact of incorrect taxon sampling arising through the lack of an appropriate evolutionary context. Through rigorous phylogenetic analyses we explain the evolutionary origins of these stains and confirm the lack of any statistical support for intra-segmental recombination. ",

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AU - Boni, Maciej F.

AU - Smith, Gavin J. D.

AU - Holmes, Edward C.

AU - Vijaykrishna, Dhanasekaran

PY - 2012/2/25

Y1 - 2012/2/25

N2 - Hao (2011) reported that the PB2 genes of three swine influenza A viruses were likely generated through homologous recombination between two closely related parental strains. However, we show that Hao's observation is an artifact of incorrect taxon sampling arising through the lack of an appropriate evolutionary context. Through rigorous phylogenetic analyses we explain the evolutionary origins of these stains and confirm the lack of any statistical support for intra-segmental recombination.

AB - Hao (2011) reported that the PB2 genes of three swine influenza A viruses were likely generated through homologous recombination between two closely related parental strains. However, we show that Hao's observation is an artifact of incorrect taxon sampling arising through the lack of an appropriate evolutionary context. Through rigorous phylogenetic analyses we explain the evolutionary origins of these stains and confirm the lack of any statistical support for intra-segmental recombination.

KW - Genome

KW - Influenza A virus

KW - Pandemic influenza

KW - Swine influenza

UR - https://www.scopus.com/pages/publications/84862809561

UR - http://ac.els-cdn.com.ezproxy.lib.monash.edu.au/S0378111911006354/1-s2.0-S0378111911006354-main.pdf?_tid=94ab4446-a7d2-11e6-8d20-00000aab0f6b&acdnat=1478843536_ce3e49843f4ff79bca5ac68149c123a8

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DO - 10.1016/j.gene.2011.10.041

M3 - Letter

C2 - 22226809

AN - SCOPUS:84862809561

SN - 0378-1119

VL - 494

SP - 242

EP - 245

JO - Gene

JF - Gene

IS - 2

ER -

No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swine

Abstract

Keywords

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