No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry

Maria Pia Campagna; Eva Kubala Havrdova; Dana Horakova; Guillermo Izquierdo; Fuencisla Matesanz; Sara Eichau; Jeannette Lechner-Scott; Bruce V. Taylor; Maria Isabel García-Sanchéz; Antonio Alcina; Anneke van der Walt; Helmut Butzkueven; Vilija G. Jokubaitis

doi:10.1177/13524585241240406

No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry

Maria Pia Campagna, Eva Kubala Havrdova, Dana Horakova, Guillermo Izquierdo, Fuencisla Matesanz, Sara Eichau, Jeannette Lechner-Scott, Bruce V. Taylor, Maria Isabel García-Sanchéz, Antonio Alcina, Anneke van der Walt, Helmut Butzkueven, Vilija G. Jokubaitis

Department of Neuroscience

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Abstract

Background: The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity. Methods: We examined the top variant, rs10191329, from Harroud et al.’s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity. Results: Our analysis revealed no significant association between rs10191329 genotype and longitudinal binary disease severity (p > 0.05). Conclusion: These findings highlight the complexity of genetic factors mediating long-term MS outcomes and the need for further research.

Original language	English
Pages (from-to)	1216 –1220
Number of pages	5
Journal	Multiple Sclerosis Journal
Volume	30
Issue number	9
DOIs	https://doi.org/10.1177/13524585241240406
Publication status	Published - Aug 2024

Keywords

disease severity
genetics
Multiple sclerosis

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10.1177/13524585241240406Licence: CC BY

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Campagna, M. P., Havrdova, E. K., Horakova, D., Izquierdo, G., Matesanz, F., Eichau, S., Lechner-Scott, J., Taylor, B. V., García-Sanchéz, M. I., Alcina, A., van der Walt, A., Butzkueven, H., & Jokubaitis, V. G. (2024). No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry. Multiple Sclerosis Journal, 30(9), 1216 –1220. https://doi.org/10.1177/13524585241240406

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title = "No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry",

abstract = "Background: The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity. Methods: We examined the top variant, rs10191329, from Harroud et al.{\textquoteright}s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity. Results: Our analysis revealed no significant association between rs10191329 genotype and longitudinal binary disease severity (p > 0.05). Conclusion: These findings highlight the complexity of genetic factors mediating long-term MS outcomes and the need for further research.",

keywords = "disease severity, genetics, Multiple sclerosis",

author = "Campagna, {Maria Pia} and Havrdova, {Eva Kubala} and Dana Horakova and Guillermo Izquierdo and Fuencisla Matesanz and Sara Eichau and Jeannette Lechner-Scott and Taylor, {Bruce V.} and Garc{\'i}a-Sanch{\'e}z, {Maria Isabel} and Antonio Alcina and {van der Walt}, Anneke and Helmut Butzkueven and Jokubaitis, {Vilija G.}",

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year = "2024",

month = aug,

doi = "10.1177/13524585241240406",

language = "English",

volume = "30",

pages = "1216 –1220",

journal = "Multiple Sclerosis Journal",

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Campagna, MP, Havrdova, EK, Horakova, D, Izquierdo, G, Matesanz, F, Eichau, S, Lechner-Scott, J, Taylor, BV, García-Sanchéz, MI, Alcina, A, van der Walt, A , Butzkueven, H & Jokubaitis, VG 2024, 'No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry', Multiple Sclerosis Journal, vol. 30, no. 9, pp. 1216 –1220. https://doi.org/10.1177/13524585241240406

No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry. / Campagna, Maria Pia; Havrdova, Eva Kubala; Horakova, Dana et al.
In: Multiple Sclerosis Journal, Vol. 30, No. 9, 08.2024, p. 1216 –1220.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry

AU - Campagna, Maria Pia

AU - Havrdova, Eva Kubala

AU - Horakova, Dana

AU - Izquierdo, Guillermo

AU - Matesanz, Fuencisla

AU - Eichau, Sara

AU - Lechner-Scott, Jeannette

AU - Taylor, Bruce V.

AU - García-Sanchéz, Maria Isabel

AU - Alcina, Antonio

AU - van der Walt, Anneke

AU - Butzkueven, Helmut

AU - Jokubaitis, Vilija G.

PY - 2024/8

Y1 - 2024/8

N2 - Background: The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity. Methods: We examined the top variant, rs10191329, from Harroud et al.’s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity. Results: Our analysis revealed no significant association between rs10191329 genotype and longitudinal binary disease severity (p > 0.05). Conclusion: These findings highlight the complexity of genetic factors mediating long-term MS outcomes and the need for further research.

AB - Background: The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity. Methods: We examined the top variant, rs10191329, from Harroud et al.’s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity. Results: Our analysis revealed no significant association between rs10191329 genotype and longitudinal binary disease severity (p > 0.05). Conclusion: These findings highlight the complexity of genetic factors mediating long-term MS outcomes and the need for further research.

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No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry

Abstract

Keywords

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Re: Genetics of multiple sclerosis severity: The importance of statistical power in replication studies and Re: From discovery to replication: Power and definitions matter for multiple sclerosis severity

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