TY - JOUR
T1 - No association of the DRD2 polymorphism and attention deficit hyperactivity disorder in the Irish population
AU - Kirley, A.
AU - Hawi, Z.
AU - Mullins, C.
AU - Fitzgerald, M.
AU - Gill, M.
N1 - Abstracts of Presentations: Eighth World Congress on Psychiatric Genetics, Versailles, France
Section: POSTERS Attention Deficit Hyperactivity Disorder
PY - 2000/8/7
Y1 - 2000/8/7
N2 - Attention Deficit Hyperactivity Disorder (ADHD) is a common disorder of childhood characterized by inattention, excessive motor activity, impulsivity, and distractibility. It is associated with serious disability in children, adolescents and adults. Pharmacological and biochemical studies have suggested a dopaminergic and nor-adrenergic systems involvement. The DRD2 polymorphisms 'TaqI' and Ser-Cys/ 311 have been implicated in the aetiology of alcoholism, schizophrenia and other psychiatric disorders. It was postulated that Ser-Cys/311might produce conformational change of the receptor by forming new disulphide bond. Functional analysis of the Ser-Cys showed that the rare Cys variant is markedly less effective in inhibiting cAMP synthesis. We investigated the transmission of both polymorphisms in ADHD cases from Ireland using the haplotype based haplotype relative risk design. There was slight and non-significant preferential transmission of the 'TaqI' allele1( 2=1.8,p=0.18) and Ser-Cys/311(Ser allele) ( 2=1.74,p=0.18) A larger sample would be required to confirm or discard this observation.
AB - Attention Deficit Hyperactivity Disorder (ADHD) is a common disorder of childhood characterized by inattention, excessive motor activity, impulsivity, and distractibility. It is associated with serious disability in children, adolescents and adults. Pharmacological and biochemical studies have suggested a dopaminergic and nor-adrenergic systems involvement. The DRD2 polymorphisms 'TaqI' and Ser-Cys/ 311 have been implicated in the aetiology of alcoholism, schizophrenia and other psychiatric disorders. It was postulated that Ser-Cys/311might produce conformational change of the receptor by forming new disulphide bond. Functional analysis of the Ser-Cys showed that the rare Cys variant is markedly less effective in inhibiting cAMP synthesis. We investigated the transmission of both polymorphisms in ADHD cases from Ireland using the haplotype based haplotype relative risk design. There was slight and non-significant preferential transmission of the 'TaqI' allele1( 2=1.8,p=0.18) and Ser-Cys/311(Ser allele) ( 2=1.74,p=0.18) A larger sample would be required to confirm or discard this observation.
UR - http://www.scopus.com/inward/record.url?scp=33749096069&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:33749096069
SN - 1552-4841
VL - 96
SP - 488
JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
IS - 4
ER -
