No association between TPH2 gene polymorphisms and ADHD in a UK sample

Karen Sheehan, Ziarih Hawi, Michael Gill, Lindsey Kent

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Tryptophan Hydroxylase 2 (TPH2) is the rate-limiting enzyme in the biosynthesis of serotonin which is exclusively expressed in the brain. Recent molecular studies reported significant association between markers mapped to TPH2 and psychiatric conditions including ADHD. We have examined four single nucleotide polymorphisms (SNPs) two of which (rs1843809, rs1386493) were reported to associate with ADHD in an Irish ADHD sample. Transmission disequilibrium analysis revealed no significant association between any of these markers and ADHD. Dividing by the sex of the transmitting parent has also failed to replicate the previously reported paternal over-transmission of the associated alleles to ADHD probands. A larger sample size will be required to clarify if TPH2 alleles are or are not associated with ADHD.

Original languageEnglish
Pages (from-to)105-107
Number of pages3
JournalNeuroscience Letters
Volume412
Issue number2
DOIs
Publication statusPublished - 29 Jan 2007
Externally publishedYes

Keywords

  • Attention Deficit Hyperactivity Disorder (ADHD)
  • Genetic association
  • Serotonergic system
  • Transmission disequilibrium test (TDT)
  • Tryptophan Hydroxylase 2 (TPH2)

Cite this

Sheehan, Karen ; Hawi, Ziarih ; Gill, Michael ; Kent, Lindsey. / No association between TPH2 gene polymorphisms and ADHD in a UK sample. In: Neuroscience Letters. 2007 ; Vol. 412, No. 2. pp. 105-107.
@article{b3e5c4be95cd4d18a1c45de452968690,
title = "No association between TPH2 gene polymorphisms and ADHD in a UK sample",
abstract = "Tryptophan Hydroxylase 2 (TPH2) is the rate-limiting enzyme in the biosynthesis of serotonin which is exclusively expressed in the brain. Recent molecular studies reported significant association between markers mapped to TPH2 and psychiatric conditions including ADHD. We have examined four single nucleotide polymorphisms (SNPs) two of which (rs1843809, rs1386493) were reported to associate with ADHD in an Irish ADHD sample. Transmission disequilibrium analysis revealed no significant association between any of these markers and ADHD. Dividing by the sex of the transmitting parent has also failed to replicate the previously reported paternal over-transmission of the associated alleles to ADHD probands. A larger sample size will be required to clarify if TPH2 alleles are or are not associated with ADHD.",
keywords = "Attention Deficit Hyperactivity Disorder (ADHD), Genetic association, Serotonergic system, Transmission disequilibrium test (TDT), Tryptophan Hydroxylase 2 (TPH2)",
author = "Karen Sheehan and Ziarih Hawi and Michael Gill and Lindsey Kent",
year = "2007",
month = "1",
day = "29",
doi = "10.1016/j.neulet.2006.10.043",
language = "English",
volume = "412",
pages = "105--107",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier",
number = "2",

}

No association between TPH2 gene polymorphisms and ADHD in a UK sample. / Sheehan, Karen; Hawi, Ziarih; Gill, Michael; Kent, Lindsey.

In: Neuroscience Letters, Vol. 412, No. 2, 29.01.2007, p. 105-107.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - No association between TPH2 gene polymorphisms and ADHD in a UK sample

AU - Sheehan, Karen

AU - Hawi, Ziarih

AU - Gill, Michael

AU - Kent, Lindsey

PY - 2007/1/29

Y1 - 2007/1/29

N2 - Tryptophan Hydroxylase 2 (TPH2) is the rate-limiting enzyme in the biosynthesis of serotonin which is exclusively expressed in the brain. Recent molecular studies reported significant association between markers mapped to TPH2 and psychiatric conditions including ADHD. We have examined four single nucleotide polymorphisms (SNPs) two of which (rs1843809, rs1386493) were reported to associate with ADHD in an Irish ADHD sample. Transmission disequilibrium analysis revealed no significant association between any of these markers and ADHD. Dividing by the sex of the transmitting parent has also failed to replicate the previously reported paternal over-transmission of the associated alleles to ADHD probands. A larger sample size will be required to clarify if TPH2 alleles are or are not associated with ADHD.

AB - Tryptophan Hydroxylase 2 (TPH2) is the rate-limiting enzyme in the biosynthesis of serotonin which is exclusively expressed in the brain. Recent molecular studies reported significant association between markers mapped to TPH2 and psychiatric conditions including ADHD. We have examined four single nucleotide polymorphisms (SNPs) two of which (rs1843809, rs1386493) were reported to associate with ADHD in an Irish ADHD sample. Transmission disequilibrium analysis revealed no significant association between any of these markers and ADHD. Dividing by the sex of the transmitting parent has also failed to replicate the previously reported paternal over-transmission of the associated alleles to ADHD probands. A larger sample size will be required to clarify if TPH2 alleles are or are not associated with ADHD.

KW - Attention Deficit Hyperactivity Disorder (ADHD)

KW - Genetic association

KW - Serotonergic system

KW - Transmission disequilibrium test (TDT)

KW - Tryptophan Hydroxylase 2 (TPH2)

UR - http://www.scopus.com/inward/record.url?scp=33846088812&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2006.10.043

DO - 10.1016/j.neulet.2006.10.043

M3 - Article

VL - 412

SP - 105

EP - 107

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -