NMR-determined lipoprotein subclass profile is associated with dietary composition and body size

A. M. Hodge, A. J. Jenkins, D. R. English, K. O'Dea, G. G. Giles

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)


Background and aims: Dyslipidemia is influenced by diet and body habitus. The Nuclear Magnetic Resonance spectroscopy lipoprotein subclass profile (NMR-LSP) is associated with diabetes and its vascular complications; and an NMR-LSP featuring large VLDL particles and small LDL and HDL particles is linked with cardiovascular disease (CVD). Thus interventions which favourably modify NMR-LSP may reduce risk for diabetes, its complications and CVD. The study aim was to investigate the associations between NMR-LSP, dietary composition and body size measures using data from the Melbourne Collaborative Cohort Study (MCCS). Methods and results: NMR-LSP was assessed in 313 men and 403 women (median age 54 years) randomly selected from a community-based cohort study. Diet was assessed using a specifically developed food frequency questionnaire (FFQ), and body size was assessed by body mass index (BMI) or waist:hips ratio (WHR). To simplify the 15 NMR-LSP variables, factor analysis was used to derive a single factor. Multivariate linear regression with this factor score as the dependent variable demonstrated that in men, total PUFA and n-6 dietary fat intake and BMI were associated with a more atherogenic NMR-LSP pattern; while in women dietary glycemic index and WHR demonstrated positive associations, and n-3 fat intake an inverse association. Conclusions: We developed a single factor score to summarize the NMR-LSP that has the benefit of combining all aspects of the NMR-LSP and accounting for correlations between them. We have shown correlations between the NMR-LSP and body size and dietary composition.

Original languageEnglish
Pages (from-to)603-609
Number of pages7
JournalNutrition, Metabolism and Cardiovascular Diseases
Issue number8
Publication statusPublished - Aug 2011
Externally publishedYes


  • Dietary carbohydrates
  • Dietary fats
  • Lipoprotein subclasses
  • Obesity

Cite this