NLRP3 inflammasomes link inflammation and metabolic disease

Dominic De Nardo; Eicke Latz

doi:10.1016/j.it.2011.05.004

NLRP3 inflammasomes link inflammation and metabolic disease

Dominic De Nardo, Eicke Latz

Research output: Contribution to journal › Review Article › Research › peer-review

380 Citations (Scopus)

Abstract

A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review these new developments and discuss their implications for a better understanding of inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.

Original language	English
Pages (from-to)	373-379
Number of pages	7
Journal	Trends in Immunology
Volume	32
Issue number	8
DOIs	https://doi.org/10.1016/j.it.2011.05.004
Publication status	Published - 1 Aug 2011
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1016/j.it.2011.05.004

Cite this

@article{c3e27a75588a4b16b70308e9a92647cd,

title = "NLRP3 inflammasomes link inflammation and metabolic disease",

abstract = "A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review these new developments and discuss their implications for a better understanding of inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.",

author = "\{De Nardo\}, Dominic and Eicke Latz",

year = "2011",

month = aug,

day = "1",

doi = "10.1016/j.it.2011.05.004",

language = "English",

volume = "32",

pages = "373--379",

journal = "Trends in Immunology",

issn = "1471-4906",

publisher = "Cell Press",

number = "8",

}

TY - JOUR

T1 - NLRP3 inflammasomes link inflammation and metabolic disease

AU - De Nardo, Dominic

AU - Latz, Eicke

PY - 2011/8/1

Y1 - 2011/8/1

N2 - A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review these new developments and discuss their implications for a better understanding of inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.

AB - A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review these new developments and discuss their implications for a better understanding of inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.

UR - https://www.scopus.com/pages/publications/79960920271

U2 - 10.1016/j.it.2011.05.004

DO - 10.1016/j.it.2011.05.004

M3 - Review Article

C2 - 21733753

AN - SCOPUS:79960920271

SN - 1471-4906

VL - 32

SP - 373

EP - 379

JO - Trends in Immunology

JF - Trends in Immunology

IS - 8

ER -

NLRP3 inflammasomes link inflammation and metabolic disease

Abstract

UN SDGs

Access to Document

Other files and links

Cite this