NLRP3 inflammasomes link inflammation and metabolic disease

Dominic De Nardo, Eicke Latz

Research output: Contribution to journalReview ArticleResearchpeer-review

267 Citations (Scopus)

Abstract

A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review these new developments and discuss their implications for a better understanding of inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.

Original languageEnglish
Pages (from-to)373-379
Number of pages7
JournalTrends in Immunology
Volume32
Issue number8
DOIs
Publication statusPublished - 1 Aug 2011
Externally publishedYes

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