Nitroxyl: a vasodilator of human vessels that is not susceptible to tolerance

Karen L Andrews, Natalie G Lumsden, Julie Farry, Ann-Maree Jefferis, Barbara K Kemp-Harper, Jaye P F Chin-Dusting

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24 Citations (Scopus)

Abstract

Pre-clinical studies have identified nitroxyl (HNO), the reduced congener of nitric oxide (NO*), as a potent vasodilator which is resistant to tolerance development. The present study explores the efficacy of HNO in human blood vessels and describes, for the first time, a vasodilator for humans that is not susceptible to tolerance. Human radial arteries and saphenous veins were obtained from patients undergoing coronary artery graft surgery and mounted in organ baths. Repeated vasodilator responses to the HNO donor Angeli s salt (AS) and NO* donor glyceryl trinitrate (GTN) were determined. AS- and GTN-induced concentration-dependent vasorelaxation of both human radial arteries (AS pEC50: 6.5+/-0.2; -log M) and saphenous veins (pEC50: 6.7+/-0.1) with similar potency. In human radial arteries, GTN-induced relaxation was reduced by the NO* scavenger hydroxocobalamin (HXC; P
Original languageEnglish
Pages (from-to)179 - 187
Number of pages9
JournalClinical Science
Volume129
Issue number2
DOIs
Publication statusPublished - 2015

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