Nitroxyl: a vasodilator of human vessels that is not susceptible to tolerance

Karen L Andrews; Natalie G Lumsden; Julie Farry; Ann-Maree Jefferis; Barbara K Kemp-Harper; Jaye P F Chin-Dusting

doi:10.1042/CS20140759

Nitroxyl: a vasodilator of human vessels that is not susceptible to tolerance

Karen L Andrews, Natalie G Lumsden, Julie Farry, Ann-Maree Jefferis, Barbara K Kemp-Harper, Jaye P F Chin-Dusting

Pharmacology

Research output: Contribution to journal › Article › Research › peer-review

33 Citations (Scopus)

Abstract

Pre-clinical studies have identified nitroxyl (HNO), the reduced congener of nitric oxide (NO*), as a potent vasodilator which is resistant to tolerance development. The present study explores the efficacy of HNO in human blood vessels and describes, for the first time, a vasodilator for humans that is not susceptible to tolerance. Human radial arteries and saphenous veins were obtained from patients undergoing coronary artery graft surgery and mounted in organ baths. Repeated vasodilator responses to the HNO donor Angeli s salt (AS) and NO* donor glyceryl trinitrate (GTN) were determined. AS- and GTN-induced concentration-dependent vasorelaxation of both human radial arteries (AS pEC50: 6.5+/-0.2; -log M) and saphenous veins (pEC50: 6.7+/-0.1) with similar potency. In human radial arteries, GTN-induced relaxation was reduced by the NO* scavenger hydroxocobalamin (HXC; P

Original language	English
Pages (from-to)	179 - 187
Number of pages	9
Journal	Clinical Science
Volume	129
Issue number	2
DOIs	https://doi.org/10.1042/CS20140759
Publication status	Published - 2015

Access to Document

10.1042/CS20140759

Cite this

@article{88a2d33c461e4c23a7e5f2f1d952cea1,

title = "Nitroxyl: a vasodilator of human vessels that is not susceptible to tolerance",

abstract = "Pre-clinical studies have identified nitroxyl (HNO), the reduced congener of nitric oxide (NO*), as a potent vasodilator which is resistant to tolerance development. The present study explores the efficacy of HNO in human blood vessels and describes, for the first time, a vasodilator for humans that is not susceptible to tolerance. Human radial arteries and saphenous veins were obtained from patients undergoing coronary artery graft surgery and mounted in organ baths. Repeated vasodilator responses to the HNO donor Angeli s salt (AS) and NO* donor glyceryl trinitrate (GTN) were determined. AS- and GTN-induced concentration-dependent vasorelaxation of both human radial arteries (AS pEC50: 6.5+/-0.2; -log M) and saphenous veins (pEC50: 6.7+/-0.1) with similar potency. In human radial arteries, GTN-induced relaxation was reduced by the NO* scavenger hydroxocobalamin (HXC; P",

author = "Andrews, {Karen L} and Lumsden, {Natalie G} and Julie Farry and Ann-Maree Jefferis and Kemp-Harper, {Barbara K} and Chin-Dusting, {Jaye P F}",

year = "2015",

doi = "10.1042/CS20140759",

language = "English",

volume = "129",

pages = "179 -- 187",

journal = "Clinical Science",

issn = "0143-5221",

publisher = "Portland Press Ltd.",

number = "2",

}

TY - JOUR

T1 - Nitroxyl: a vasodilator of human vessels that is not susceptible to tolerance

AU - Andrews, Karen L

AU - Lumsden, Natalie G

AU - Farry, Julie

AU - Jefferis, Ann-Maree

AU - Kemp-Harper, Barbara K

AU - Chin-Dusting, Jaye P F

PY - 2015

Y1 - 2015

N2 - Pre-clinical studies have identified nitroxyl (HNO), the reduced congener of nitric oxide (NO*), as a potent vasodilator which is resistant to tolerance development. The present study explores the efficacy of HNO in human blood vessels and describes, for the first time, a vasodilator for humans that is not susceptible to tolerance. Human radial arteries and saphenous veins were obtained from patients undergoing coronary artery graft surgery and mounted in organ baths. Repeated vasodilator responses to the HNO donor Angeli s salt (AS) and NO* donor glyceryl trinitrate (GTN) were determined. AS- and GTN-induced concentration-dependent vasorelaxation of both human radial arteries (AS pEC50: 6.5+/-0.2; -log M) and saphenous veins (pEC50: 6.7+/-0.1) with similar potency. In human radial arteries, GTN-induced relaxation was reduced by the NO* scavenger hydroxocobalamin (HXC; P

AB - Pre-clinical studies have identified nitroxyl (HNO), the reduced congener of nitric oxide (NO*), as a potent vasodilator which is resistant to tolerance development. The present study explores the efficacy of HNO in human blood vessels and describes, for the first time, a vasodilator for humans that is not susceptible to tolerance. Human radial arteries and saphenous veins were obtained from patients undergoing coronary artery graft surgery and mounted in organ baths. Repeated vasodilator responses to the HNO donor Angeli s salt (AS) and NO* donor glyceryl trinitrate (GTN) were determined. AS- and GTN-induced concentration-dependent vasorelaxation of both human radial arteries (AS pEC50: 6.5+/-0.2; -log M) and saphenous veins (pEC50: 6.7+/-0.1) with similar potency. In human radial arteries, GTN-induced relaxation was reduced by the NO* scavenger hydroxocobalamin (HXC; P

UR - http://www.clinsci.org/content/129/2/179.full-text.pdf

U2 - 10.1042/CS20140759

DO - 10.1042/CS20140759

M3 - Article

SN - 0143-5221

VL - 129

SP - 179

EP - 187

JO - Clinical Science

JF - Clinical Science

IS - 2

ER -

Nitroxyl: a vasodilator of human vessels that is not susceptible to tolerance

Abstract

Access to Document

Other files and links

Cite this