Nitroxide-loaded hexosomes provide MRI contrast in vivo

Nicole Bye; Oliver E Hutt; Tracey M Hinton; Durga P Acharya; Lynne J Waddington; Bradford Armstrong Moffat; David K Wright; Hong Xin Wang; Xavier Mulet; Benjamin Ward Muir

doi:10.1021/la5007296

Nitroxide-loaded hexosomes provide MRI contrast in vivo

Nicole Bye, Oliver E Hutt, Tracey M Hinton, Durga P Acharya, Lynne J Waddington, Bradford Armstrong Moffat, David K Wright, Hong Xin Wang, Xavier Mulet, Benjamin Ward Muir

Surgery Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

49 Citations (Scopus)

Abstract

The purpose of this work was to synthesize and screen, for their effectiveness to act as T1-enhancing magnetic resonance imaging (MRI) contrast agents, a small library of nitroxide lipids incorporated into cubic-phase lipid nanoparticles (cubosomes). The most effective nitroxide lipid was then formulated into lower-toxicity lipid nanoparticles (hexosomes), and effective MR contrast was observed in the aorta and spleen of live rats in vivo. This new class of lower-toxicity lipid nanoparticles allowed for higher relaxivities on the order of those of clinically used gadolinium complexes. The new hexosome formulation presented herein was significantly lower in toxicity and higher in relaxivity than cubosome formulations previously reported by us.

Original language	English
Pages (from-to)	8898 - 8906
Number of pages	9
Journal	Langmuir
Volume	30
Issue number	29
DOIs	https://doi.org/10.1021/la5007296
Publication status	Published - 2014

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10.1021/la5007296

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title = "Nitroxide-loaded hexosomes provide MRI contrast in vivo",

abstract = "The purpose of this work was to synthesize and screen, for their effectiveness to act as T1-enhancing magnetic resonance imaging (MRI) contrast agents, a small library of nitroxide lipids incorporated into cubic-phase lipid nanoparticles (cubosomes). The most effective nitroxide lipid was then formulated into lower-toxicity lipid nanoparticles (hexosomes), and effective MR contrast was observed in the aorta and spleen of live rats in vivo. This new class of lower-toxicity lipid nanoparticles allowed for higher relaxivities on the order of those of clinically used gadolinium complexes. The new hexosome formulation presented herein was significantly lower in toxicity and higher in relaxivity than cubosome formulations previously reported by us.",

author = "Nicole Bye and Hutt, \{Oliver E\} and Hinton, \{Tracey M\} and Acharya, \{Durga P\} and Waddington, \{Lynne J\} and Moffat, \{Bradford Armstrong\} and Wright, \{David K\} and Wang, \{Hong Xin\} and Xavier Mulet and Muir, \{Benjamin Ward\}",

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doi = "10.1021/la5007296",

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T1 - Nitroxide-loaded hexosomes provide MRI contrast in vivo

AU - Bye, Nicole

AU - Hutt, Oliver E

AU - Hinton, Tracey M

AU - Acharya, Durga P

AU - Waddington, Lynne J

AU - Moffat, Bradford Armstrong

AU - Wright, David K

AU - Wang, Hong Xin

AU - Mulet, Xavier

AU - Muir, Benjamin Ward

PY - 2014

Y1 - 2014

N2 - The purpose of this work was to synthesize and screen, for their effectiveness to act as T1-enhancing magnetic resonance imaging (MRI) contrast agents, a small library of nitroxide lipids incorporated into cubic-phase lipid nanoparticles (cubosomes). The most effective nitroxide lipid was then formulated into lower-toxicity lipid nanoparticles (hexosomes), and effective MR contrast was observed in the aorta and spleen of live rats in vivo. This new class of lower-toxicity lipid nanoparticles allowed for higher relaxivities on the order of those of clinically used gadolinium complexes. The new hexosome formulation presented herein was significantly lower in toxicity and higher in relaxivity than cubosome formulations previously reported by us.

AB - The purpose of this work was to synthesize and screen, for their effectiveness to act as T1-enhancing magnetic resonance imaging (MRI) contrast agents, a small library of nitroxide lipids incorporated into cubic-phase lipid nanoparticles (cubosomes). The most effective nitroxide lipid was then formulated into lower-toxicity lipid nanoparticles (hexosomes), and effective MR contrast was observed in the aorta and spleen of live rats in vivo. This new class of lower-toxicity lipid nanoparticles allowed for higher relaxivities on the order of those of clinically used gadolinium complexes. The new hexosome formulation presented herein was significantly lower in toxicity and higher in relaxivity than cubosome formulations previously reported by us.

UR - http://pubs.acs.org/doi/pdf/10.1021/la5007296

U2 - 10.1021/la5007296

DO - 10.1021/la5007296

M3 - Article

SN - 0743-7463

VL - 30

SP - 8898

EP - 8906

JO - Langmuir

JF - Langmuir

IS - 29

ER -

Nitroxide-loaded hexosomes provide MRI contrast in vivo

Abstract

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