Nitrous oxide and long-term morbidity and mortality in the ENIGMA trial

Kate Leslie, Paul S Myles, Matthew Chan, Andrew Forbes, Michael Paech, Philip Peyton, Brendan Silbert, Elizabeth Williamson

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Abstract

There is a plausible pathophysiologic rationale for increased long-term cardiovascular morbidity and mortality in patients receiving significant exposure to nitrous oxide. However, this relationship has not been established clinically. The ENIGMA trial randomized 2050 patients having noncardiac surgery lasting more than 2 hours to nitrous oxide-based or nitrous oxide-free anesthesia. We conducted a follow-up study of the ENIGMA patients to evaluate the risk of cardiovascular events in the longer term.
Original languageEnglish
Pages (from-to)387 - 393
Number of pages7
JournalAnesthesia and Analgesia
Volume112
Issue number2
DOIs
Publication statusPublished - 2011

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