Nitrofurantoin and fosfomycin for resistant urinary tract infections: Old drugs for emerging problems

Bradley J Gardiner; Andrew J Stewardson; Iain J. Abbott; Anton Y. Peleg

doi:10.18773/austprescr.2019.002

Nitrofurantoin and fosfomycin for resistant urinary tract infections: Old drugs for emerging problems

Bradley J Gardiner, Andrew J Stewardson, Iain J. Abbott, Anton Y. Peleg

Research output: Contribution to journal › Article › Other › peer-review

118 Citations (Scopus)

Abstract

Uncomplicated urinary tract infection is one of the most common indications for antibiotic use in the community. However, the Gram-negative organisms that can cause the infection are becoming more resistant to antibiotics. Many multidrug resistant organisms retain susceptibility to two old antibiotics, nitrofurantoin and fosfomycin. Advantages over newer drugs include their high urinary concentrations and minimal toxicity. Fosfomycin is a potential treatment option for patients with uncomplicated urinary tract infection due to resistant organisms. Nitrofurantoin may be more effective and can be used for urinary infections in pregnant women.

Original language	English
Pages (from-to)	14-19
Number of pages	6
Journal	Australian Prescriber
Volume	42
Issue number	1
DOIs	https://doi.org/10.18773/austprescr.2019.002
Publication status	Published - 1 Feb 2019

Keywords

Antibiotic resistance
Fosfomycin
Nitrofurantoin
Urinary tract infection

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10.18773/austprescr.2019.002Licence: CC BY-NC-ND

286377111-oaFinal published version, 174 KBLicence: CC BY-NC-ND

Cite this

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title = "Nitrofurantoin and fosfomycin for resistant urinary tract infections: Old drugs for emerging problems",

abstract = "Uncomplicated urinary tract infection is one of the most common indications for antibiotic use in the community. However, the Gram-negative organisms that can cause the infection are becoming more resistant to antibiotics. Many multidrug resistant organisms retain susceptibility to two old antibiotics, nitrofurantoin and fosfomycin. Advantages over newer drugs include their high urinary concentrations and minimal toxicity. Fosfomycin is a potential treatment option for patients with uncomplicated urinary tract infection due to resistant organisms. Nitrofurantoin may be more effective and can be used for urinary infections in pregnant women.",

keywords = "Antibiotic resistance, Fosfomycin, Nitrofurantoin, Urinary tract infection",

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AB - Uncomplicated urinary tract infection is one of the most common indications for antibiotic use in the community. However, the Gram-negative organisms that can cause the infection are becoming more resistant to antibiotics. Many multidrug resistant organisms retain susceptibility to two old antibiotics, nitrofurantoin and fosfomycin. Advantages over newer drugs include their high urinary concentrations and minimal toxicity. Fosfomycin is a potential treatment option for patients with uncomplicated urinary tract infection due to resistant organisms. Nitrofurantoin may be more effective and can be used for urinary infections in pregnant women.

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Nitrofurantoin and fosfomycin for resistant urinary tract infections: Old drugs for emerging problems

Abstract

Keywords

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Other files and links

Defining burden and drivers of antibiotic resistant bacteria and healthcare infections to plan costeffective interventions

NOVEL SOLUTIONS FOR ANTIMICROBIAL RESISTANT PATHOGENS

Cite this

Nitrofurantoin and fosfomycin for resistant urinary tract infections: Old drugs for emerging problems

Abstract

Keywords

Access to Document

Other files and links

Projects

Defining burden and drivers of antibiotic resistant bacteria and healthcare infections to plan costeffective interventions

NOVEL SOLUTIONS FOR ANTIMICROBIAL RESISTANT PATHOGENS

Cite this